{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐543 is emerging as a pivotal post‐transcriptional regulator that exerts context‐dependent roles in human pathology. In some cancers its deregulation appears to drive tumor progression; for example, initial studies in prostate cancer, gastric carcinoma, osteosarcoma, and even in the regulation of cellular senescence in mesenchymal stem cells indicate that altered miR‐543 expression may impact cell proliferation and differentiation by modulating key targets such as tumor suppressors or cell‐cycle regulators. This early body of work demonstrates that miR‐543 expression is frequently altered, suggesting its potential as both a biomarker and a regulator of oncogenesis and aging processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the mechanistic level, miR‐543 has been documented to regulate a diverse array of signaling pathways and cellular processes by targeting distinct mRNAs. In gastric cancer and diabetic retinopathy models, for instance, miR‐543 directly targets SIRT1—thereby promoting cell proliferation, cell cycle progression, and angiogenesis through downstream effectors and by fostering an epithelial–mesenchymal transition. Similar regulatory loops have been observed in esophageal, colorectal, clear cell renal, and certain lung cancers where miR‐543 modulates oncogenic factors including PLA2G4A, PTEN, PRMT9, and KLF6. Its oncogenic activities are further underscored in viral myocarditis, pituitary adenomas, nasopharyngeal carcinoma, and oral squamous cell carcinoma via repression of targets such as DNAJB1, Smad7, JAM‐A, CYP3A5, and MTA1. In contrast, in glioma and a subset of ovarian cancers, miR‐543 appears to function as a tumor suppressor by attenuating proliferation and invasion—underscoring that its biological effects are highly context‐ and tissue–dependent. Importantly, a series of studies also reveal that long non–coding RNAs (including linc-PINT, SNHG10, and others) can “sponge” miR‐543, thereby modulating its availability and downstream activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond cancer, miR‐543 has been implicated in other pathological conditions including metabolic dysfunction, chemoresistance, neurodegeneration, and inflammatory injury. Studies in breast cancer, colorectal cancer, cervical cancer, ovarian cancer (including exosome–mediated transfer), glioma, lung adenocarcinoma, small–cell lung carcinoma, and even leukemia underscore that modulating miR‐543 levels can influence cell survival, migration, invasion, and drug sensitivity. In several instances, targeting the miR‐543 regulatory axis—whether by modulating its expression directly or by interfering with its upstream long non–coding RNAs such as GATA6–AS1—restores the expression of critical tumor suppressors (e.g., PTEN, SIRT1, TWIST1, VCAN) and has therapeutic potential. Collectively, these findings highlight the complexity, context-dependency, and translational promise of miR‐543 as both a prognostic marker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yang Du, Xiu-Heng Liu, Heng-Cheng Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000464120"}], "href": "https://doi.org/10.1159/000464120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28245474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28245474"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Juan Li, Guoying Dong, Bo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-543 promotes gastric cancer cell proliferation by targeting SIRT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.11.062"}], "href": "https://doi.org/10.1016/j.bbrc.2015.11.062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26612257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26612257"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Heng Zhang, Xiaofeng Guo, Xing Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-543 promotes osteosarcoma cell proliferation and glycolysis by partially suppressing PRMT9 and stabilizing HIF-1α protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13672"}], "href": "https://doi.org/10.18632/oncotarget.13672"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27911265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27911265"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Seunghee Lee, Kyung-Rok Yu, Young-Sil Ryu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Age (Dordr) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11357-014-9724-2"}], "href": "https://doi.org/10.1007/s11357-014-9724-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25465621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25465621"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaoying Liu, Lu Gan, Jing Zhang "}, {"type": "b", "children": [{"type": "t", "text": "miR-543 inhibites cervical cancer growth and metastasis by targeting TRPM7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chem Biol Interact (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cbi.2019.01.036"}], "href": "https://doi.org/10.1016/j.cbi.2019.01.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30710498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30710498"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Huaying Zhao, Changying Diao, Xiaohui Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-543 Promotes Migration, Invasion and Epithelial-Mesenchymal Transition of Esophageal Cancer Cells by Targeting Phospholipase A2 Group IVA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000492281"}], "href": "https://doi.org/10.1159/000492281"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30071514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30071514"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ning Ke, Lian-Hong Pi, Qing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG7 inhibits high glucose-induced human retinal endothelial cells angiogenesis by regulating miR-543/SIRT1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.04.141"}], "href": "https://doi.org/10.1016/j.bbrc.2019.04.141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31056258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31056258"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yanyan Shi, Ziwei Yang, Ting Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SIRT1-targeted miR-543 autophagy inhibition and epithelial-mesenchymal transition promotion in Helicobacter pylori CagA-associated gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1859-8"}], "href": "https://doi.org/10.1038/s41419-019-1859-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31423013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31423013"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lingmin Zhang, Jingxin Chen, Li Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc-PINT acted as a tumor suppressor by sponging miR-543 and miR-576-5p in esophageal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28699"}], "href": "https://doi.org/10.1002/jcb.28699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31464068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31464068"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Gang Liu, JianPing Zhou, Ming Dong "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of miR-543 expression increases the sensitivity of colorectal cancer cells to 5-Fluorouracil through the PTEN/PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20190249"}], "href": "https://doi.org/10.1042/BSR20190249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30842340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30842340"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Liang Xu, Ju Yu, Zhongyong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-543 functions as a tumor suppressor in glioma in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5712"}], "href": "https://doi.org/10.3892/or.2017.5712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28627653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28627653"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Shu Wang, Wenyang Jiang, Xinghua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC-PINT alleviates lung cancer progression via sponging miR-543 and inducing PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2822"}], "href": "https://doi.org/10.1002/cam4.2822"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31981466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31981466"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Fan Yang, Jianjun Ma, Qisheng Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-543 promotes the proliferation and invasion of clear cell renal cell carcinoma cells by targeting Krüppel-like factor 6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.10.136"}], "href": "https://doi.org/10.1016/j.biopha.2017.10.136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29101805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29101805"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Kun Xia, Yong Zhang, Dongming Sun "}, {"type": "b", "children": [{"type": "t", "text": "miR‑217 and miR‑543 downregulation mitigates inflammatory response and myocardial injury in children with viral myocarditis by regulating the SIRT1/AMPK/NF‑κB signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2019.4442"}], "href": "https://doi.org/10.3892/ijmm.2019.4442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31894309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31894309"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jian Sun, Jianping Zhou, Ming Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulation of MicroRNA-543 expression in colorectal cancer promotes tumor migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22489"}], "href": "https://doi.org/10.1002/mc.22489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27148794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27148794"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Xiaojing Hu, Liyi Chi, Wentao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.11.032"}], "href": "https://doi.org/10.1016/j.bbrc.2015.11.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26562529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26562529"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zhe Zhang, Li Nong, Meng-Lei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biother Radiopharm (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/cbr.2019.3334"}], "href": "https://doi.org/10.1089/cbr.2019.3334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32319822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32319822"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Liping Wang, Weihong Chen, Jun Zha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑543 acts as a novel oncogene in oral squamous cell carcinoma by targeting CYP3A5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7230"}], "href": "https://doi.org/10.3892/or.2019.7230"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31322243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31322243"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Dawei Wang, Li Cai, Xudong Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-543 promotes tumorigenesis and angiogenesis in non-small cell lung cancer via modulating metastasis associated protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s10020-020-00175-1"}], "href": "https://doi.org/10.1186/s10020-020-00175-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32410569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32410569"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Bernd O Evert, Rohit Nalavade, Johannes Jungverdorben, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0201794"}], "href": "https://doi.org/10.1371/journal.pone.0201794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30086154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30086154"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Da-Wei Shen, Yun-Long Li, Yu-Jie Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Biotechnol Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09168451.2019.1591260"}], "href": "https://doi.org/10.1080/09168451.2019.1591260"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30973065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30973065"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xue Jiang, Baoqiang Dai, Lichun Feng "}, {"type": "b", "children": [{"type": "t", "text": "miR-543 promoted the cell proliferation and invasion of nasopharyngeal carcinoma by targeting the JAM-A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-019-00274-0"}], "href": "https://doi.org/10.1007/s13577-019-00274-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31428943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31428943"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Q Yu, Z Zhang, B He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-543 functions as tumor suppressor in ovarian cancer by targeting TWIST1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Regul Homeost Agents (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.23812/19-567-A"}], "href": "https://doi.org/10.23812/19-567-A"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32148011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32148011"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Enrique Fuentes-Mattei, Recep Bayraktar, Taghi Manshouri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.121781"}], "href": "https://doi.org/10.1172/jci.insight.121781"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31941838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31941838"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Rong Li, Sihao Hou, Ming Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-543 impairs cell proliferation, migration, and invasion in breast cancer by suppressing VCAN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.07.005"}], "href": "https://doi.org/10.1016/j.bbrc.2021.07.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34293593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34293593"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "D-W Su, X Li, J Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-543 inhibits proliferation and metastasis of human colorectal cancer cells by targeting PLAS3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202009_22820"}], "href": "https://doi.org/10.26355/eurrev_202009_22820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32964969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32964969"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Nan Feifei, Zhang Mingzhi, Zhang Yanyun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA expression analysis of mammospheres cultured from human breast cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-012-1272-5"}], "href": "https://doi.org/10.1007/s00432-012-1272-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22752669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22752669"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Huimin Dang, Pengsheng Zheng, Yu Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-543 acts as a prognostic marker and promotes the cell proliferation in cervical cancer by BRCA1-interacting protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317691187"}], "href": "https://doi.org/10.1177/1010428317691187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28231728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28231728"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Shupei Zhang, Diling Pan, Shaoyu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-543 Inhibits the Proliferation of Ovarian Cancer by Targeting IGF2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/2003739"}], "href": "https://doi.org/10.1155/2022/2003739"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35391781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35391781"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Tao Ji, Xiejun Zhang, Weiping Li "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑543 inhibits proliferation, invasion and induces apoptosis of glioblastoma cells by directly targeting ADAM9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7332"}], "href": "https://doi.org/10.3892/mmr.2017.7332"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28849046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28849046"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Youwen Xu, Ling Lin, Dongqing Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-LINC01089 inhibits lung adenocarcinoma cell proliferation and promotes apoptosis via sponging miR-543."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tissue Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tice.2021.101535"}], "href": "https://doi.org/10.1016/j.tice.2021.101535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33892399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33892399"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Jian-Feng Meng, Ming-Jie Luo, Hai-Bin Li "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of miR-543 Inhibits the Proliferation and Migration of Small-Cell Lung Carcinoma Cells and Induces Apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2021037227"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2021037227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34347977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34347977"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Ling Sun, Jun Lu, Tan-Tan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Regulatory Effect of MiR-543 on Proliferation and Apoptosis of Human Leukemia Cell Line K562 and Its Mechanism]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Shi Yan Xue Ye Xue Za Zhi (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.19746/j.cnki.issn.1009-2137.2019.03.020"}], "href": "https://doi.org/10.19746/j.cnki.issn.1009-2137.2019.03.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31204929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31204929"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Yi Jin, Daqing Jiang "}, {"type": "b", "children": [{"type": "t", "text": "GATA6-AS1 via Sponging miR-543 to Regulate PTEN/AKT Signaling Axis Suppresses Cell Proliferation and Migration in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediators Inflamm (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2023/9340499"}], "href": "https://doi.org/10.1155/2023/9340499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37273453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37273453"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Y L Wang, R H Liang, C Y Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-543 inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of triple-negative breast cancer cells via down-regulation of ACTL6A gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-021-02672-z"}], "href": "https://doi.org/10.1007/s12094-021-02672-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34181232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34181232"}]}]}]}