{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted the importance of precise regulatory mechanisms in diverse pathological contexts. One investigation examined the role of epigenetic modifiers—including the transcription factor YY1 and the demethylase TET2—in the differentiation and antioxidative maturation of stem cell–derived endothelial‐like cells. Although this work (which focused on inflammation, oxidative stress, and vascular repair) did not directly assess MIR544B, it establishes a framework in which miRNA‐mediated post‐transcriptional control may intersect with epigenetic regulation in cellular responses"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n<br><br>\nIn a separate study addressing advanced gastric cancer, MIR544B (also referred to as miR-544) was found to be significantly upregulated within cancer cell–derived extracellular vesicles from patients exhibiting peritoneal metastasis. This upregulation facilitates the transfer of MIR544B to peritoneal mesothelial cells, where it directly suppresses the expression of the tumor suppressor gene PLZF. The resultant loss of PLZF enhances mesothelial cell migration and invasion, thereby contributing to the progression of peritoneal metastases"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n<br><br>\nCollectively, these findings suggest that MIR544B serves as a critical modulator in pathological settings: while its direct involvement in endothelial cell differentiation remains to be elucidated, its established role in downregulating PLZF in gastric cancer underscores its potential as both a diagnostic biomarker and a therapeutic target. Further research is warranted to explore how MIR544B and similar miRNAs might integrate with epigenetic networks to influence cellular fate and disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianming Guo, Qiuling Xiang, Yaojie Xin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-544 promotes maturity and antioxidation of stem cell-derived endothelial like cells by regulating the YY1/TET2 signalling axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Commun Signal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12964-019-0504-6"}], "href": "https://doi.org/10.1186/s12964-019-0504-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32127022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32127022"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wencheng Kong, Xinchun Liu, Guang Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular vesicle derived miR-544 downregulates expression of tumor suppressor promyelocytic leukemia zinc finger resulting in increased peritoneal metastasis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.104082"}], "href": "https://doi.org/10.18632/aging.104082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33221764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33221764"}]}]}]}