{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided abstracts reveals that they predominantly focus on the roles and regulatory mechanisms of retinal and olfactory guanylyl cyclases, as well as associated calcium‐ and magnesium‐binding proteins and signaling pathways. None of these studies, however, mention or discuss the function of MIR548AE1. In particular, one study details how guanylyl cyclase-activating proteins (GCAPs) operate as Ca2+/Mg2+ sensor proteins critical for photoreceptor guanylyl cyclase regulation (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", while another elucidates the genetic and developmental orchestrations guiding the axonal wiring of GC-D+ neurons in the olfactory system (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther abstracts in the collection address mutations in retinal guanylyl cyclase 1 associated with inherited retinal degeneration (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "and mechanisms underlying socially transmitted odor preferences mediated by GC-D+ olfactory sensory neurons (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Additionally, one study tests the consequences of specific GUCY2D mutations linked to Leber congenital amaurosis (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Despite these detailed insights into sensory signaling and cyclic GMP synthesis, none of the abstracts include any data or discussion concerning MIR548AE1.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Igor V Peshenko, Alexander M Dizhoor "}, {"type": "b", "children": [{"type": "t", "text": "Guanylyl cyclase-activating proteins (GCAPs) are Ca2+/Mg2+ sensors: implications for photoreceptor guanylyl cyclase (RetGC) regulation in mammalian photoreceptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C400065200"}], "href": "https://doi.org/10.1074/jbc.C400065200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14993224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14993224"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andreas Walz, Paul Feinstein, Mona Khan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.008722"}], "href": "https://doi.org/10.1242/dev.008722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17942483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17942483"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Alexander M Dizhoor, Elena V Olshevskaya, Igor V Peshenko "}, {"type": "b", "children": [{"type": "t", "text": "The R838S Mutation in Retinal Guanylyl Cyclase 1 (RetGC1) Alters Calcium Sensitivity of cGMP Synthesis in the Retina and Causes Blindness in Transgenic Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.755553"}], "href": "https://doi.org/10.1074/jbc.M116.755553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27703005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27703005"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Arthur D Zimmerman, Christina R Nagy, Steven D Munger "}, {"type": "b", "children": [{"type": "t", "text": "Sensory neurons expressing the atypical olfactory receptor guanylyl cyclase D are required for the acquisition of odor preferences by mice in diverse social contexts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Behav (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.physbeh.2020.113150"}], "href": "https://doi.org/10.1016/j.physbeh.2020.113150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32841674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32841674"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sanford L Boye, Elena V Olshevskaya, Igor V Peshenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional study of two biochemically unusual mutations in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "GUCY2D"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Leber congenital amaurosis expressed via adenoassociated virus vector in mouse retinas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Vis (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27881908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27881908"}]}]}]}