{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided does not report any data or insights regarding the function of MIR548AE2. Instead, all four abstracts focus on the roles and regulation of Keratin 7 (K7) in various epithelial tissues under distinct physiological and pathological conditions. For example, one study characterized a K7 knockout mouse and demonstrated that loss of K7 increases urothelial proliferation in the bladder, along with tissue‐specific alterations in its partners (e.g., K18 and K20)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAnother investigation used luciferase reporter systems and transgenic mice to dissect the regulatory elements of the murine K7 promoter, establishing that key upstream sequences are required for selective expression in pancreatic ductal cells and pancreatic cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA further report extended the understanding of K7 by showing its presence in the islets of Langerhans, where K7 forms part of an intermediate filament network that is modulated by K18 levels and is markedly altered in experimental diabetes, underscoring its role in maintaining islet cellular architecture."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLastly, research on septic lung injury revealed that phosphorylation of a unique site on K7 can provoke the disintegration of desmosomal proteins, contributing to alveolar barrier dysfunction in acute lung injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, while these investigations provide substantial insight into the diverse functions of Keratin 7 in epithelial biology, none of the abstracts address or elucidate the function of MIR548AE2.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aileen Sandilands, Frances J D Smith, Declan P Lunny, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Generation and characterisation of keratin 7 (K7) knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0064404"}], "href": "https://doi.org/10.1371/journal.pone.0064404"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23741325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23741325"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Judit Pujal, Meritxell Huch, Anabel José, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.08-115576"}], "href": "https://doi.org/10.1096/fj.08-115576"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19124560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19124560"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Catharina M Alam, Sarah Baghestani, Ada Pajari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22157784"}], "href": "https://doi.org/10.3390/ijms22157784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34360548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34360548"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qi He, Zirui Zuo, Ke Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2023.110867"}], "href": "https://doi.org/10.1016/j.intimp.2023.110867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37660597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37660597"}]}]}]}