{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-548ag functions as an oncogene in the context of obesity‐related endometrial cancer. Elevated levels of this microRNA are found in the serum of obese patients with endometrial cancer, and its high expression correlates with a poorer survival rate. Mechanistically, miR-548ag directly targets and suppresses the expression of MOB1B, a core component of the Hippo signaling pathway. This inhibition of MOB1B leads to deactivation of Hippo signaling, thereby facilitating increased proliferation, invasion, and migration of cancer cells, while simultaneously inhibiting apoptosis. The overall consequence of miR-548ag overexpression is the promotion of tumor progression in obesity‐associated endometrial cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huai Pang, Jingzhou Wang, Qianqian Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15679"}], "href": "https://doi.org/10.1111/cas.15679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36445107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36445107"}]}]}]}