{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nObesity is a recognized high‐risk factor for endometrial cancer, and recent findings indicate that miR-548ag is significantly overexpressed in the sera of obese individuals with this disease. Elevated levels of miR-548ag are associated with a poorer overall survival in patients, highlighting its potential role as an oncogenic biomarker in obesity-related endometrial cancer. This microRNA appears to contribute to tumor progression by promoting malignant cellular behaviors in the context of an obesogenic environment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn mechanistic terms, miR-548ag directly targets and suppresses the expression of MOB1B, a core component of the Hippo signaling pathway. By downregulating MOB1B, miR-548ag deactivates the Hippo pathway, resulting in enhanced cell proliferation, invasion, and migration, while simultaneously inhibiting apoptosis in endometrial cancer cells. These molecular events collectively drive the aggressiveness of the tumor in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huai Pang, Jingzhou Wang, Qianqian Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15679"}], "href": "https://doi.org/10.1111/cas.15679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36445107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36445107"}]}]}]}