{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn coronary artery disease, far infrared radiation (FIR) treatment was found to improve the angiogenic function of endothelial colony forming cells (ECFCs) by promoting tube formation. A key molecular event underlying this functional enhancement is the down‐regulation of miR-548aq-3p, which normally acts as an inhibitor of tube formation. Functional studies further demonstrated that overexpressing miR-548aq-3p impedes the tube formation capacity of ECFCs, whereas its inhibition is associated with improved angiogenic activity. These findings suggest that the down-regulation of miR-548aq-3p contributes significantly to the therapeutic benefit of FIR in CAD patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, emerging studies underscore the growing diagnostic value of circulating microRNAs in oncology. Although a separate investigation evaluated whole blood microRNAs as biomarkers for breast cancer axillary lymph node metastasis, a specific role for miR-548aq-3p in this cancer context was not delineated. This highlights the broader potential of microRNAs as non-invasive biomarkers while also pointing to the need for further research to clarify whether miR-548aq-3p may additionally have diagnostic or mechanistic relevance in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei-Che Tsai, Wei-Hui Chiang, Chun-Hsien Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-548aq-3p is a novel target of Far infrared radiation which predicts coronary artery disease endothelial colony forming cell responsiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-63311-1"}], "href": "https://doi.org/10.1038/s41598-020-63311-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32322002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32322002"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bin Yang, Ya-Wen Wang, Lin-Hui Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulated miR-367-3p, miR-548aq-5p, and miR-4710 in Human Whole Blood: Potential Biomarkers for Breast Cancer With Axillary Lymph Node Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Breast Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clbc.2022.11.011"}], "href": "https://doi.org/10.1016/j.clbc.2022.11.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36564279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36564279"}]}]}]}