{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR548AT (also known as miR-548at-5p) is a microRNA that has been examined for its role in disease susceptibility, particularly in Parkinson’s disease (PD). In a case‐control study involving a Chinese Han population, researchers investigated a single‐nucleotide polymorphism (rs11651671:A>G) in MIR548AT and found no statistically significant association with PD risk. This finding suggests that, at least in this population, MIR548AT does not appear to contribute substantially to PD genetic susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWhile the direct function of MIR548AT in PD remains inconclusive, its evaluation is set against a broader context of RNA-based regulation as demonstrated in several studies. For instance, research into intron retention mechanisms showed that RNA-binding proteins like BUD13 facilitate proper splicing and consequent gene expression, thereby impacting immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, a study in glioblastoma underscored how the BUD13/CDK12/MBNL1 axis plays a key role in tumor vasculogenic mimicry, suggesting that dysregulation of post-transcriptional regulators can have profound cellular consequences."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther illustrating the importance of RNA regulatory networks, investigations in colorectal cancer have revealed that long non-coding RNAs can recruit proteins such as BUD13 to stabilize target mRNAs and activate oncogenic signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Although these studies primarily focus on other aspects of RNA regulation, they provide important context for understanding the complex interplay of microRNAs like MIR548AT within cellular regulatory systems. Thus, while MIR548AT’s specific impact on PD susceptibility appears limited based on current evidence, further research is necessary to elucidate its broader functional roles across different biological processes and disease contexts.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fang Li, Han Liu, Yuan Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of variants in microRNA with Parkinson's disease in Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10072-017-3210-4"}], "href": "https://doi.org/10.1007/s10072-017-3210-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29209904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29209904"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Luke Frankiw, Devdoot Majumdar, Christian Burns, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BUD13 Promotes a Type I Interferon Response by Countering Intron Retention in Irf7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2018.11.038"}], "href": "https://doi.org/10.1016/j.molcel.2018.11.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30639243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30639243"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Meichen Liu, Xuelei Ruan, Xiaobai Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-05426-z"}], "href": "https://doi.org/10.1038/s41419-022-05426-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36463205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36463205"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shengwei Zhuang, Weihong Lu, Lianjun Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the progression of colorectal cancer through recruiting BUD13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2023_230612N303"}], "href": "https://doi.org/10.4149/neo_2023_230612N303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38053379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38053379"}]}]}]}