{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nhsa‐miR-548ba is a microRNA expressed in human pre-ovulatory granulosa cells—in particular, it is generated from an intronic region of the FSH receptor gene—and plays a regulatory role in ovarian follicle development. Functional studies in the KGN cell line have demonstrated that hsa‐miR-548ba directly targets several key genes, including LIFR and PTEN, as well as NEO1 and SP110. Through these interactions, the microRNA is proposed to influence signaling pathways that control follicle growth and activation, thereby contributing to the fine-tuning of granulosa cell function and proper folliculogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, by modulating important regulators such as LIFR and PTEN, hsa‐miR-548ba may indirectly affect cellular processes like proliferation, differentiation, and survival within the ovarian microenvironment. These findings underscore the emerging role of intra-genic microRNAs in coordinating the complex networks that govern ovarian function, and they lay the groundwork for further studies to explore both normal follicle maturation and potential reproductive pathologies associated with dysregulation of this miRNA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ilmatar Rooda, Kati Hensen, Birgitta Kaselt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-59186-x"}], "href": "https://doi.org/10.1038/s41598-020-59186-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32042028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32042028"}]}]}]}