{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐548c is emerging as an important regulatory molecule in diverse physiological and pathological contexts. In the cardiovascular system, profiling of peripheral blood mononuclear cells from patients with dilated cardiomyopathy and chronic heart failure has revealed a marked downregulation of miR‐548 family members – including miR‐548c – pointing to its potential as an early diagnostic biomarker. In preeclampsia, reduced levels of miR‐548c‐5p in serum exosomes and placental mononuclear cells lead to derepression of its target PTPRO, thereby enhancing macrophage activation via the NF‐κB pathway and contributing to the pronounced inflammatory state observed in the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncology, miR‐548c exhibits predominantly tumor‐suppressive functions across a spectrum of malignancies. Investigations in gynecological cancers have highlighted its role in endometrial and ovarian tumorigenesis, suggesting that miR‐548c may serve as a “universe” miRNA in these contexts. In colorectal cancer, for instance, miR‐548c‐5p is significantly downregulated, resulting in elevated levels of the glycolytic enzyme PGK1 and concomitant increases in cellular proliferation and inflammatory cytokine production. Similarly, deregulation of miR‐548c‐3p has been associated with tumor progression in papillary thyroid carcinoma. In addition, studies in breast cancer further underscore the capacity of miR‐548c‐5p to modulate tumor phenotypes, while in hepatocellular carcinoma the loss of miR‐548c‐3p—often through sequestration by oncogenic circular RNAs—leads to overexpression of LAMC2 and promotion of epithelial–mesenchymal transition. In osteosarcoma, miR‐548c‐3p negatively regulates cell proliferation and invasion, further reinforcing its tumor‐suppressive role."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in inflammation and oncogenesis, miR‐548c also plays a part in cellular differentiation processes. In kidney podocytes, miR‐548c‐5p regulates the expression of the transcription factor FOXC2 by binding to a remote upstream target region, thereby fine‐tuning FOXC2 levels during podocyte differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the antiviral arena, particularly in chronic hepatitis B, miR‐548c‐3p functions as a negative regulator of the interferon‐inducible effector TRIM22. Elevated miR‐548c‐3p expression in interferon non‐responsive patients leads to suppression of TRIM22, thereby reducing downstream activation of key cytokines in the NOD2/NF‐κB pathway and ultimately weakening the therapeutic efficacy of interferon treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Manveen K Gupta, Carmel Halley, Zhong-Hui Duan, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MiR-548c-3p suppressed the progression of papillary thyroid carcinoma via inhibition of the HIF1α-mediated VEGF signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201908_18543"}], "href": "https://doi.org/10.26355/eurrev_201908_18543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31378898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31378898"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "S-Z He, Q Wang "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-548c-5p inhibits the proliferation of breast cancer cells through regulating Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202004_20845"}], "href": "https://doi.org/10.26355/eurrev_202004_20845"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32329856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32329856"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jinglan Jin, Huan Liu, Meishan Jin, et al. 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