MIR548D1 Gene

HGNC Family Non-coding RNAs
Name microRNA 548d-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐548d—in its various mature forms such as miR‐548d‑5p and miR‐548d‑3p—functions as a critical post‐transcriptional regulator in multiple biological contexts. In human bone marrow mesenchymal stem cells, miR‐548d‑5p has been implicated in modulating cell fate decisions by targeting peroxisome proliferator‐activated receptor‑γ (PPARγ), thereby promoting dexamethasone-induced adipogenic differentiation at the expense of osteogenic outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of tumorigenesis, miR‐548d‑3p exerts tumor-suppressive functions. In one study, miR‐548d‑3p was shown to specifically target and cooperate with other microRNAs to repress ERBB2 expression in cancer cells, providing molecular support for miRNA-based targeted therapy. In another investigation, reduced levels of miR‐548d‑3p in osteosarcoma were associated with upregulation of the oncogene KRAS, and restoration of miR‐548d‑3p expression inhibited cell growth and migration, further underscoring its potential as a therapeutic agent in cancer treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, miR‐548d‑3p has been implicated in modulating the immune response during infection. In studies of American Tegumentary Leishmaniasis, upregulation of this miRNA in infected host cells and in the plasma of self-healed patients was correlated with altered chemokine production. Inhibition experiments further revealed that miR‐548d‑3p influences the inflammatory milieu by targeting components of the chemokine signaling pathway, suggesting its promise as both a prognostic marker and a therapeutic target in modulating pathogenic inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junkui Sun, Yisheng Wang, Yuebai Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of PPARγ by miR-548d-5p suppresses the adipogenic differentiation of human bone marrow mesenchymal stem cells and enhances their osteogenic potential."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1479-5876-12-168"}], "href": "https://doi.org/10.1186/1479-5876-12-168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24929254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24929254"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hong Chen, Jian Guo Sun, Xue-Wu Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preliminary validation of ERBB2 expression regulated by miR-548d-3p and miR-559."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.05.113"}], "href": "https://doi.org/10.1016/j.bbrc.2009.05.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19486885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19486885"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianhua Chen, Chongnan Yan, Honghao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-548d-3p inhibits osteosarcoma by downregulating "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "KRAS"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102097"}], "href": "https://doi.org/10.18632/aging.102097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31327761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31327761"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marina de Assis Souza, Eduardo Milton Ramos-Sanchez, Sandra Márcia Muxel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-548d-3p Alters Parasite Growth and Inflammation in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Leishmania (Viannia) braziliensis"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Infect Microbiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcimb.2021.687647"}], "href": "https://doi.org/10.3389/fcimb.2021.687647"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34178725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34178725"}]}]}]}
Synonyms MIRN548D1
NCBI Gene ID 693130
API
Download Associations
Predicted Functions View MIR548D1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR548D1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR548D1's ARCHS4 Predicted Functions.

Functional Associations

MIR548D1 has 331 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR548D1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548D1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548D1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR548D1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548D1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR548D1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548D1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR548D1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR548D1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR548D1 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR548D1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548D1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR548D1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR548D1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR548D1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.