MIR548D2 Gene

HGNC Family Non-coding RNAs
Name microRNA 548d-2
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have implicated members of the miR‐548d family in diverse physiological processes. In human bone marrow mesenchymal stem cells, bioinformatic analysis identified miR‐548d‐5p as a candidate regulator of peroxisome proliferator-activated receptor-γ (PPARγ), suggesting that this miRNA may influence the balance between adipogenic and osteogenic differentiation under dexamethasone induction. This observation highlights a potential role of miR‐548d in modulating mesenchymal cell fate and tissue regeneration processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, miR‐548d‐3p has been shown to exert tumor‐suppressive functions. One study demonstrated that miR‐548d‐3p, particularly when co-expressed with miR‐559, specifically interacts with the 3′-UTR of ERBB2 mRNA to cooperatively inhibit its translation in tumors with ERBB2 overexpression. Similarly, reduced levels of miR‐548d‐3p in osteosarcoma correlate with enhanced activity of oncogenic KRAS, with restoration of miR‐548d‐3p markedly reducing cell growth and migration in vitro."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn infectious diseases, particularly leishmaniasis, miR‐548d‐3p appears to play a critical role in modulating the host immune response. In American Tegumentary Leishmaniasis, upregulation of miR‐548d‐3p in infected monocytes and plasma from self-healed patients was associated with altered chemokine production—including MCP1/CCL2, RANTES/CCL5, and IP10/CXCL10—that may favor lesion resolution. Moreover, in visceral leishmaniasis, inhibition of miR‐548d‐3p led to enhanced parasite growth, potentially due to diminished MCP-1 and nitric oxide production, underscoring its significance in orchestrating effective inflammatory responses during infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junkui Sun, Yisheng Wang, Yuebai Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of PPARγ by miR-548d-5p suppresses the adipogenic differentiation of human bone marrow mesenchymal stem cells and enhances their osteogenic potential."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1479-5876-12-168"}], "href": "https://doi.org/10.1186/1479-5876-12-168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24929254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24929254"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hong Chen, Jian Guo Sun, Xue-Wu Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preliminary validation of ERBB2 expression regulated by miR-548d-3p and miR-559."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.05.113"}], "href": "https://doi.org/10.1016/j.bbrc.2009.05.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19486885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19486885"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianhua Chen, Chongnan Yan, Honghao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-548d-3p inhibits osteosarcoma by downregulating "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "KRAS"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102097"}], "href": "https://doi.org/10.18632/aging.102097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31327761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31327761"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marina de Assis Souza, Eduardo Milton Ramos-Sanchez, Sandra Márcia Muxel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-548d-3p Alters Parasite Growth and Inflammation in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Leishmania (Viannia) braziliensis"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Infect Microbiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcimb.2021.687647"}], "href": "https://doi.org/10.3389/fcimb.2021.687647"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34178725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34178725"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Eduardo Milton Ramos-Sanchez, Luiza Campos Reis, Marina de Assis Souza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-548d-3p Is Up-Regulated in Human Visceral Leishmaniasis and Suppresses Parasite Growth in Macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Infect Microbiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcimb.2022.826039"}], "href": "https://doi.org/10.3389/fcimb.2022.826039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35265535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35265535"}]}]}]}
Synonyms MIRN548D2
NCBI Gene ID 693131
API
Download Associations
Predicted Functions View MIR548D2's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR548D2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR548D2's ARCHS4 Predicted Functions.

Functional Associations

MIR548D2 has 242 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR548D2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548D2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548D2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR548D2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548D2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR548D2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548D2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR548D2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR548D2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR548D2 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR548D2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR548D2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548D2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR548D2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR548D2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR548D2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.