MIR548F1 Gene

HGNC Family Non-coding RNAs
Name microRNA 548f-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe abstracts provided do not report any direct information regarding the function of MIR548F1. Instead, these studies focus on elucidating the roles of protein regulators involved in cytoskeletal dynamics and cellular remodeling. For example, one study shows that the tyrosine kinase Pyk2 (30626696) functions at postsynaptic sites, where its kinase activity and interaction with the RhoGAP protein Graf1 modulate RhoA-dependent control of actin stability, thereby influencing dendritic spine maintenance and synaptic integrity relevant to Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA second investigation characterizes the function of the Rho-GAP protein GRAF1 (25019370) in myoblast fusion. In this work, GRAF1 is shown to promote actin remodeling and mediate vesicle-associated transport of fusogenic proteins to the plasma membrane, a process critical for the formation and maturation of multinucleated muscle fibers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTwo additional studies (38081847, 38855880) further elucidate the role of GRAF1/ARHGAP26 in mitochondrial quality control. In these reports, upon phosphorylation by PINK1 and interaction with Parkin, GRAF1 supports actin remodeling around damaged mitochondria, facilitating the capture of these organelles by autophagosomes to promote mitophagy—a process whose dysregulation is linked to cardiometabolic and neurological disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThus, while the functionality of key proteins such as Pyk2 and GRAF1/ARHGAP26 in synaptic regulation, muscle cell fusion, and mitochondrial clearance is comprehensively described, none of the abstracts mention or discuss the role of MIR548F1. The available data do not provide insights into MIR548F1’s function in any of these contexts.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Suho Lee, Santiago V Salazar, Timothy O Cox, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2983-18.2018"}], "href": "https://doi.org/10.1523/JNEUROSCI.2983-18.2018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30626696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30626696"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kaitlin C Lenhart, Abby L Becherer, Jianbin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GRAF1 promotes ferlin-dependent myoblast fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2014.06.025"}], "href": "https://doi.org/10.1016/j.ydbio.2014.06.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25019370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25019370"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qiang Zhu, Matthew E Combs, Juan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-023-43889-6"}], "href": "https://doi.org/10.1038/s41467-023-43889-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38081847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38081847"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qiang Zhu, Joan M Taylor "}, {"type": "b", "children": [{"type": "t", "text": "ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2024.2361576"}], "href": "https://doi.org/10.1080/15548627.2024.2361576"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38855880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38855880"}]}]}]}
Synonyms HSA-MIR-548F-1, MIR548F-1, MIRN548F1
NCBI Gene ID 100302192
API
Download Associations
Predicted Functions View MIR548F1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR548F1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR548F1's ARCHS4 Predicted Functions.

Functional Associations

MIR548F1 has 198 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR548F1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548F1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR548F1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548F1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR548F1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548F1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR548F1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR548F1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR548F1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548F1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR548F1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR548F1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR548F1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.