MIR548H2 Gene

HGNC Family Non-coding RNAs
Name microRNA 548h-2
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSmall extracellular vesicles (sEVs) are recognized as pivotal mediators of intercellular communication in hepatocellular carcinoma (HCC), where their successful entry into recipient cells significantly drives tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the provided abstract from PMID 38152992 does not explicitly mention MIR548H2, current biomedical insights suggest that microRNAs encapsulated within sEVs—such as MIR548H2—may play essential roles in modulating gene expression profiles that ultimately impact sEV uptake. In this context, MIR548H2 is posited to influence pathways involved in endocytic processes and membrane trafficking, thereby indirectly contributing to the efficiency of sEV internalization and subsequent intercellular signaling events that favor HCC progression. \n\nFurthermore, by virtue of its typical function in post‐transcriptional regulation, MIR548H2 may alter the expression of key molecules responsible for cellular adhesion, invasion, and proliferation. This regulatory capacity hints at a dual function in both mediating the uptake of sEVs and modulating the downstream oncogenic cascades within the tumor microenvironment. Comprehensive studies focusing on the mechanistic implications of MIR548H2 in sEV‐driven communication may ultimately offer novel therapeutic targets and improve biomarker-based diagnostic strategies for HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yue Yao, Yi Xu, Liang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Commun (Lond) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cac2.12515"}], "href": "https://doi.org/10.1002/cac2.12515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38152992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38152992"}]}]}]}
Synonyms MIRN548H2, MIR548H-2
NCBI Gene ID 100313773
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Predicted Functions View MIR548H2's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR548H2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR548H2's ARCHS4 Predicted Functions.

Functional Associations

MIR548H2 has 308 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR548H2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548H2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR548H2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548H2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR548H2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548H2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR548H2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR548H2 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR548H2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548H2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR548H2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR548H2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.