MIR548I1 Gene

HGNC Family Non-coding RNAs
Name microRNA 548i-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have uncovered novel regulatory pathways in specialized cell types, exemplified by the modulation of autophagy in immune cells. In primary dendritic cells, exposure to interleukin‐4 during differentiation induces the expression of the adaptor protein RUFY4, which positively regulates macroautophagy via mTORC1 inhibition. RUFY4 enhances the formation of autophagosomes marked by LC3 and Syntaxin 17, thereby promoting lysosome tethering and efficient endogenous antigen presentation that aids in pathogen clearance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Recent investigations in hepatocellular carcinoma have delineated a distinct regulatory mechanism involving noncoding RNAs. Here, the circular RNA circNFATC3 acts as a molecular sponge for hsa‐miR-548I1, a microRNA that, when active, normally targets the mRNA of NFATC3. By sequestering miR-548I1, circNFATC3 protects NFATC3 from downregulation, leading to inhibition of the phosphorylation cascades of JNK, c-Jun, AKT, and mTOR. This regulatory axis exerts tumor suppressor functions, as restoration of NFATC3 correlates with reduced hepatoma cell proliferation, migration/invasion, and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "In a separate context, the adaptor protein RUFY4 also plays a critical role in bone remodeling. During osteoclastogenesis, RUFY4 is upregulated and facilitates the fusion between late endosomes and lysosomes by bridging Rab7 on endosomes with LAMP2 on lysosomes, a process essential for the exocytotic release of degradative enzymes such as cathepsin K. Disruption of RUFY4 impairs lysosomal trafficking, leading to defective bone resorption and protection against pathological bone loss in models of osteoclast‐mediated disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Seigo Terawaki, Voahirana Camosseto, Francesca Prete, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201501059"}], "href": "https://doi.org/10.1083/jcb.201501059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26416964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26416964"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Changchang Jia, Zhicheng Yao, Zexiao Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29931"}], "href": "https://doi.org/10.1002/jcp.29931"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32667692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32667692"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Minhee Kim, Jin Hee Park, Miyeon Go, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41413-024-00326-8"}], "href": "https://doi.org/10.1038/s41413-024-00326-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38744829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38744829"}]}]}]}
Synonyms MIRN548I1, HSA-MIR-548I-1, MIR-548I-1, MIR548I-1
NCBI Gene ID 100302204
API
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Predicted Functions View MIR548I1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR548I1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR548I1's ARCHS4 Predicted Functions.

Functional Associations

MIR548I1 has 174 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR548I1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548I1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548I1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR548I1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548I1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548I1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR548I1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR548I1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR548I1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548I1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.