MIR548K Gene

HGNC Family Non-coding RNAs
Name microRNA 548k
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that miR-548k functions as a post‐transcriptional regulator in immune-related conditions. In thymic tissues from myasthenia gravis patients with thymic hyperplasia, for example, miR-548k was found to negatively modulate CXCL13 mRNA expression, suggesting a role in controlling chemokine levels and immune cell recruitment that may contribute to the disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of breast cancer, miR-548k is significantly overexpressed compared to adjacent normal tissues, where it exerts its oncogenic influence by targeting and downregulating PTEN—a critical negative regulator of the PI3K/Akt pathway. This suppression disrupts programmed cell death and enhances cell proliferation, highlighting a pivotal miR-548k/PTEN/PI3K/Akt axis that could serve as a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, integrative genomic analyses in head and neck squamous cell carcinoma have identified MIR548K as a key amplicon driver that contributes to epithelial–mesenchymal transition. This finding underlines the microRNA’s multifaceted role across different cancer types, reinforcing its significance as a modulator of oncogenic processes and a candidate for targeted intervention strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jinpin Li, Di Qiu, Zezhi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-548k regulates CXCL13 expression in myasthenia gravis patients with thymic hyperplasia and in Jurkat cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jneuroim.2018.03.021"}], "href": "https://doi.org/10.1016/j.jneuroim.2018.03.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29661539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29661539"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mahtab Yadollahi-Farsani, Zeinab Amini-Farsani, Fatemeh Moayedi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-548k suppresses apoptosis in breast cancer cells by affecting PTEN/PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.2688"}], "href": "https://doi.org/10.1002/iub.2688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36309967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36309967"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Céline I Mahieu, Andrew G Mancini, Ellee P Vikram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-23-0746"}], "href": "https://doi.org/10.1158/1541-7786.MCR-23-0746"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37930255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37930255"}]}]}]}
Synonyms MIRN548K
NCBI Gene ID 100313770
API
Download Associations
Predicted Functions View MIR548K's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR548K's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR548K's ARCHS4 Predicted Functions.

Functional Associations

MIR548K has 328 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR548K from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548K gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548K gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR548K gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548K gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR548K gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR548K gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR548K gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR548K gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR548K gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR548K gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR548K gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR548K gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR548K gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR548K gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.