{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies in human hepatocellular carcinoma have revealed that MIR548L acts as a tumor suppressor by targeting the sialyltransferase gene ST3GAL5, thereby influencing key aspects of metastasis. In highly invasive versus lower metastatic potential cell lines, manipulating MIR548L expression altered malignant behaviors and oncogenicity both in vitro and in vivo, suggesting a crucial role in modulating cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn non‐small cell lung cancer, MIR548L is implicated in controlling cell migration and invasion. Although the mechanistic details are still being elucidated, its regulatory impact on these processes highlights its potential as a modulator of tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, research in neuroblastoma has demonstrated that MIR548L levels are downregulated in both 11q-deleted and MYCN-amplified tumor types. Restoration of MIR548L in neuroblastoma cell lines resulted in reduced proliferation, cell cycle arrest, and enhanced apoptosis, underpinning its role as an important tumor suppressor whose loss may contribute to the aggressive nature of the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hongjiao Cai, Huimin Zhou, Yuan Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2017.12"}], "href": "https://doi.org/10.1038/labinvest.2017.12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28218742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28218742"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Caihong Liu, Huan Yang, Zhijie Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-548l is involved in the migration and invasion of non-small cell lung cancer by targeting the AKT1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-014-1836-7"}], "href": "https://doi.org/10.1007/s00432-014-1836-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25245053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25245053"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sanja Jurcevic, Simon Keane, Emmy Borgmästars, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioinformatics analysis of miRNAs in the neuroblastoma 11q-deleted region reveals a role of miR-548l in both 11q-deleted and MYCN amplified tumour cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-24140-6"}], "href": "https://doi.org/10.1038/s41598-022-24140-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36396668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36396668"}]}]}]}