{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nEvidence from studies in the lymphoma microenvironment indicates that MIR548M plays a critical role in regulating oncogenic signaling pathways. In mantle cell and other non‐Hodgkin lymphomas, stromal cell interactions trigger a c-Myc/miR-548m feed-forward loop whereby sustained c-Myc activation leads to the downregulation of miR-548m. This reduction in miR-548m levels subsequently contributes to an increase in histone deacetylase 6 (HDAC6) expression, which facilitates enhanced cell survival, clonogenicity, and drug resistance. These findings suggest that MIR548M functions as a tumor-suppressive factor by modulating epigenetic regulators and survival pathways critical for lymphoma progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional insights into the molecular role of MIR548M emerge from studies examining miRNA binding sites within coding sequences of specific mRNAs. In this context, MIR548M, together with other family members such as miR-548j and miR-548d-5p, has been shown to target conserved binding sites in the mRNA of PTPN12 orthologs. These interactions occur in regions encoding short, conserved oligopeptides, underscoring the evolutionary preservation and likely functional significance of this miRNA-mRNA regulatory module in modulating gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tint Lwin, Xiaohong Zhao, Fengdong Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI64210"}], "href": "https://doi.org/10.1172/JCI64210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24216476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24216476"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anatoliy T Ivashchenko, Assel S Issabekova, Olga A Berillo "}, {"type": "b", "children": [{"type": "t", "text": "miR-1279, miR-548j, miR-548m, and miR-548d-5p binding sites in CDSs of paralogous and orthologous PTPN12, MSH6, and ZEB1 Genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2013/902467"}], "href": "https://doi.org/10.1155/2013/902467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23957009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23957009"}]}]}]}