{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into microRNA‐mediated regulation of lipid metabolism have highlighted several miRs that modulate the expression of apolipoprotein B (apoB), the essential protein scaffold in very‐low-density lipoprotein assembly implicated in hyperlipidemia and atherosclerosis. In this context, MIR548P is being evaluated for its potential role in post‐transcriptionally downregulating apoB, thereby contributing to the modulation of lipid levels and vascular health. Although detailed mechanistic insights into MIR548P’s function remain to be fully characterized, its inclusion among the candidates aimed at reducing apoB expression underscores the broader therapeutic promise of miRs in targeting lipid metabolism disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liye Zhou, M Mahmood Hussain "}, {"type": "b", "children": [{"type": "t", "text": "Human MicroRNA-548p Decreases Hepatic Apolipoprotein B Secretion and Lipid Synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.117.309247"}], "href": "https://doi.org/10.1161/ATVBAHA.117.309247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28336556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28336556"}]}]}]}