{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided studies directly investigate MIR548T, together they describe an integrin‐associated adhesion network in which MIR548T could conceivably play a regulatory role. Several reports characterize the molecular underpinnings of focal adhesion assembly mediated by the integrin-linked kinase (ILK) complex. For example, one study detailed the conserved genomic organization and broad tissue expression of the parvin family (which, along with ILK and PINCH, forms the core IPP complex) that is essential for integrin signaling (1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations emphasize the tissue-specific consequences of disrupting these adhesion complexes. Loss of α-parvin in vascular smooth muscle cells leads to hypercontractility and impaired vessel remodeling, while endothelial adhesion and angiogenesis critically depend on proper integrin-mediated contacts. Similarly, ablation of ILK–parvin interactions perturbs mammary epithelial differentiation and keratinocyte attachment required for epidermal morphogenesis, collectively underscoring that precise IPP complex function is essential for vascular, epithelial, and mesenchymal cell behavior."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies extend these findings to specialized structures; proper assembly of the IPP complex is vital for podocyte adhesion and maintenance of the glomerular filtration barrier, and for regulating chondrocyte rotation in growth plates to ensure normal long bone development. In this context, the evolutionary conservation and regulatory importance of parvins further underscore the impact of perturbations in integrin-cytoskeleton linkages. Although the specific biological function of MIR548T was not addressed in any of these reports, the collective emphasis on integrin signaling and focal adhesion integrity suggests that further exploration of MIR548T’s potential regulatory influence in these pathways is warranted."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanqiang Yang, Lida Guo, Simone M Blattner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2004121112"}], "href": "https://doi.org/10.1681/ASN.2004121112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15872073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15872073"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fabio Stanchi, Carsten Grashoff, Carine Flore Nguemeni Yonga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.044602"}], "href": "https://doi.org/10.1242/jcs.044602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19435803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19435803"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eloi Montanez, Sara A Wickström, Johannes Altstätter, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.117.305818"}], "href": "https://doi.org/10.1161/CIRCRESAHA.117.305818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25925587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25925587"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nicholas Rooney, Pengbo Wang, Keith Brennan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Integrin-Mediated ILK-Parvin-αPix Signaling Axis Controls Differentiation in Mammary Epithelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.25390"}], "href": "https://doi.org/10.1002/jcp.25390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27019299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27019299"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bettina Pitter, Ann-Cathrin Werner, Eloi Montanez "}, {"type": "b", "children": [{"type": "t", "text": "Parvins Are Required for Endothelial Cell-Cell Junctions and Cell Polarity During Embryonic Blood Vessel Formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.118.310840"}], "href": "https://doi.org/10.1161/ATVBAHA.118.310840"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29567677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29567677"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Johannes Altstätter, Michael W Hess, Mercedes Costell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0230380"}], "href": "https://doi.org/10.1371/journal.pone.0230380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32163511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32163511"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "E Korenbaum, T M Olski, A A Noegel "}, {"type": "b", "children": [{"type": "t", "text": "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0378-1119(01)00743-0"}], "href": "https://doi.org/10.1016/s0378-1119(01"}, {"type": "t", "text": "00743-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11722847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11722847"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Manuel Rogg, Jasmin I Maier, Clara Van Wymersch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "α-Parvin Defines a Specific Integrin Adhesome to Maintain the Glomerular Filtration Barrier."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2021101319"}], "href": "https://doi.org/10.1681/ASN.2021101319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35260418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35260418"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jifan Yuan, Ling Guo, Jiaxin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "α-parvin controls chondrocyte column formation and regulates long bone development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41413-023-00284-7"}], "href": "https://doi.org/10.1038/s41413-023-00284-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37607905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37607905"}]}]}]}