{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a high-content, microscopy‐based screen of 2,565 miRNA mimics in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), hsa-miR-548v—a primate-specific miRNA—was identified as the most potent enhancer of myocardial relaxation velocity. Its positive lusitropic effect, observed both in standard hiPSC-CMs and in engineered cardiac tissues harboring the BRAF T599R mutation, occurred independently of alterations in calcium transients. Mechanistically, RNA-Seq analysis revealed that hsa-miR-548v downregulates several components of the mechanosensing machinery, most notably diminishing ANKRD1/CARP1 expression and its localization at the sarcomeric I-band. These findings indicate that this critical sarcomeric region not only governs cardiomyocyte relaxation but also provides a promising target for therapeutic approaches aimed at alleviating diastolic dysfunction in heart failure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Eva Vermersch, Salomé Neuvendel, Charlène Jouve, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hsa-miR-548v controls the viscoelastic properties of human cardiomyocytes and improves their relaxation rates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.161356"}], "href": "https://doi.org/10.1172/jci.insight.161356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38165745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38165745"}]}]}]}