{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA survey of these studies underscores the central importance of the IKKβ/NF‑κB signaling cascade in coordinating inflammatory responses, cell survival, metabolism, and tissue homeostasis across multiple organ systems—including liver, muscle, brain, skin, and the gastrointestinal tract."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, none of these abstracts explicitly investigate or mention MIR548W—a microRNA that, like other members of the MIR548 family, may regulate gene expression post‐transcriptionally. Although the studies provide extensive insight into how IKKβ/NF‑κB signaling governs inflammatory, metabolic, and oncogenic pathways, the potential role of MIR548W in modulating these processes (for example, by targeting mRNAs that encode key signaling molecules within the NF‑κB cascade) remains undetermined and unexplored in the current literature."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, although a rich body of literature details how aberrant IKKβ/NF‑κB signaling contributes to chronic inflammation, metabolic dysregulation, tissue injury, and tumorigenesis across a variety of systems, the current collection of abstracts provides no direct insights into the function of MIR548W. Consequently, while MIR548W—by virtue of its membership in a microRNA family known to regulate gene expression—is a plausible candidate for modulating aspects of NF‑κB activity and its downstream targets, its specific biological role remains to be elucidated by future targeted research efforts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dongsheng Cai, Minsheng Yuan, Daniel F Frantz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1166"}], "href": "https://doi.org/10.1038/nm1166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15685173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15685173"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Melek C Arkan, Andrea L Hevener, Florian R Greten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IKK-beta links inflammation to obesity-induced insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1185"}], "href": "https://doi.org/10.1038/nm1185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15685170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15685170"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoqing Zhang, Guo Zhang, Hai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2008.07.043"}], "href": "https://doi.org/10.1016/j.cell.2008.07.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18854155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18854155"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dongsheng Cai, J Daniel Frantz, Nicholas E Tawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IKKbeta/NF-kappaB activation causes severe muscle wasting in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2004.09.027"}], "href": "https://doi.org/10.1016/j.cell.2004.09.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15479644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15479644"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shin Maeda, Hideaki Kamata, Jun-Li Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2005.04.014"}], "href": "https://doi.org/10.1016/j.cell.2005.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15989949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15989949"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Florian R Greten, Melek C Arkan, Julia Bollrath, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2007.07.009"}], "href": "https://doi.org/10.1016/j.cell.2007.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17803913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17803913"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Keiko Kawauchi, Keigo Araki, Kei Tobiume, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1724"}], "href": "https://doi.org/10.1038/ncb1724"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18391940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18391940"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Colby Zaph, Amy E Troy, Betsy C Taylor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature05590"}], "href": "https://doi.org/10.1038/nature05590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17322906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17322906"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Manolis Pasparakis, Gilles Courtois, Martin Hafner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature00820"}], "href": "https://doi.org/10.1038/nature00820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12075355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12075355"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Swarnali Acharyya, S Armando Villalta, Nadine Bakkar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI30556"}], "href": "https://doi.org/10.1172/JCI30556"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17380205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17380205"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Niki L Reynaert, Albert van der Vliet, Amy S Guala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0603290103"}], "href": "https://doi.org/10.1073/pnas.0603290103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16916935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16916935"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Fan Yang, Eric Tang, Kunliang Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.170.11.5630"}], "href": "https://doi.org/10.4049/jimmunol.170.11.5630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12759443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12759443"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hiroaki Sakurai, Shunsuke Suzuki, Noritaka Kawasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M301598200"}], "href": "https://doi.org/10.1074/jbc.M301598200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12842894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12842894"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Juxue Li, Yizhe Tang, Dongsheng Cai "}, {"type": "b", "children": [{"type": "t", "text": "IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2562"}], "href": "https://doi.org/10.1038/ncb2562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22940906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22940906"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Foteini Mourkioti, Paschalis Kratsios, Tom Luedde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI28721"}], "href": "https://doi.org/10.1172/JCI28721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17080195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17080195"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jin Zhang, Zhanguo Gao, Jun Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M806480200"}], "href": "https://doi.org/10.1074/jbc.M806480200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18952604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18952604"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Oliver Herrmann, Bernd Baumann, Rossana de Lorenzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IKK mediates ischemia-induced neuronal death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1323"}], "href": "https://doi.org/10.1038/nm1323"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16286924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16286924"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Keiko Kawauchi, Keigo Araki, Kei Tobiume, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0813210106"}], "href": "https://doi.org/10.1073/pnas.0813210106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19202066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19202066"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Mikyoung Chang, Wei Jin, Shao-Cong Sun "}, {"type": "b", "children": [{"type": "t", "text": "Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.1777"}], "href": "https://doi.org/10.1038/ni.1777"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19734906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19734906"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Eleni Maniati, Maud Bossard, Natalie Cook, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI45797"}], "href": "https://doi.org/10.1172/JCI45797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22056382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22056382"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Xiang Li, Paul E Massa, Adedayo Hanidu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M205165200"}], "href": "https://doi.org/10.1074/jbc.M205165200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12221085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12221085"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Qingyuan Meng, Dongsheng Cai "}, {"type": "b", "children": [{"type": "t", "text": "Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.254417"}], "href": "https://doi.org/10.1074/jbc.M111.254417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21784844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21784844"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Johannes A Schmid, Andreas Birbach "}, {"type": "b", "children": [{"type": "t", "text": "IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine Growth Factor Rev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cytogfr.2008.01.006"}], "href": "https://doi.org/10.1016/j.cytogfr.2008.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18308615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18308615"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jason A Gustin, Osman N Ozes, Hakan Akca, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M306976200"}], "href": "https://doi.org/10.1074/jbc.M306976200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14585846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14585846"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Laurence J Egan, Lars Eckmann, Florian R Greten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0306734101"}], "href": "https://doi.org/10.1073/pnas.0306734101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14983030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14983030"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Harald J Maier, Tobias G Schips, Astrid Wietelmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1116584109"}], "href": "https://doi.org/10.1073/pnas.1116584109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22753500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22753500"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Lars Eckmann, Tim Nebelsiek, Alexander A Fingerle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Opposing functions of IKKbeta during acute and chronic intestinal inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0808216105"}], "href": "https://doi.org/10.1073/pnas.0808216105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18815378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18815378"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Yifeng Xia, Roanna C Padre, Tatiana Hurtado De Mendoza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0812256106"}], "href": "https://doi.org/10.1073/pnas.0812256106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19196987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19196987"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Wen-Hui Hu, Julie S Pendergast, Xian-Ming Mo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M501670200"}], "href": "https://doi.org/10.1074/jbc.M501670200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15951441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15951441"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Panayiotis Victoratos, Jacques Lagnel, Sotiria Tzima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2005.11.013"}], "href": "https://doi.org/10.1016/j.immuni.2005.11.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16413924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16413924"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Bernd Baumann, Martin Wagner, Tamara Aleksic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI30876"}], "href": "https://doi.org/10.1172/JCI30876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17525799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17525799"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Alison M O'Mahony, Mauricio Montano, Katrien Van Beneden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401397200"}], "href": "https://doi.org/10.1074/jbc.M401397200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14963024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14963024"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Hiroaki Fujita, Simin Rahighi, Mariko Akita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism underlying IκB kinase activation mediated by the linear ubiquitin chain assembly complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01538-13"}], "href": "https://doi.org/10.1128/MCB.01538-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24469399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24469399"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Li-Chung Hsu, Thomas Enzler, Jun Seita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.1976"}], "href": "https://doi.org/10.1038/ni.1976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21170027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21170027"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Nancy C Moss, William E Stansfield, Monte S Willis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00776.2007"}], "href": "https://doi.org/10.1152/ajpheart.00776.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17675566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17675566"}]}]}]}