{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study demonstrates that exosomal miR‑548x‑3p, derived from human bone marrow mesenchymal stem cells, functions as a protective regulator in heat stroke by mitigating the pyroptosis of vascular endothelial cells. In heat stroke patients, miR‑548x‑3p expression is reduced; however, its enrichment in BMSC‑derived exosomes facilitates inhibition of the HMGB1/NLRP3 signaling axis, thereby decreasing the expression of key inflammasome components (HGMB1, NLRP3, ASC, caspase‑1, and GSDMD‑N) and reducing the secretion of pro‑inflammatory cytokines such as IL‑1β, IL‑18, and TNF‑α."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOverall, the findings highlight the therapeutic potential of utilizing exosomal miR‑548x‑3p mimics to counteract the detrimental inflammatory and pyroptotic processes in heat stroke, offering promising insights for future interventions aimed at protecting vital organs from heat‑induced injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanfang Pei, Wenfeng Ma, Huifang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mesenchymal stem cell-derived exosomal miR-548x-3p inhibits pyroptosis of vascular endothelial cells through HMGB1 in heat stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2023.110719"}], "href": "https://doi.org/10.1016/j.ygeno.2023.110719"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37757977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37757977"}]}]}]}