{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided reveals a wealth of information on the multifaceted functions of Vanin‑1, a membrane‐bound pantetheinase, in a broad range of pathological contexts. In liver disease models, hepatocyte‐derived microparticles—whose proangiogenic capacity in steatohepatitis is critically dependent on Vanin‑1—serve as intercellular signals contributing to pathological angiogenesis and liver injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations have demonstrated that Vanin‑1 plays a central role as an oxidative stress sensor and regulator of inflammation. Loss of Vanin‑1 leads to enhanced glutathione synthesis, conferring resistance to oxidative injury and dampening inflammatory responses in models of radiation, chemical toxicity, and colitis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn developmental biology, Vanin‑1 expression is tightly regulated in a sex‐specific manner in the fetal gonad where it is activated by key transcription factors such as SF‑1 and SOX9. This regulation is essential for establishing the proper microenvironment required for male germ cell development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn liver metabolism, Vanin‑1 is upregulated in fasting and insulin resistant states. Its transcriptional activation by factors including PGC‑1α and HNF‑4α leads to increased gluconeogenic gene expression and hepatic glucose output, suggesting its potential as a therapeutic target in metabolic diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nVanin‑1 also influences immune cell recruitment and activation; for instance, its presence modulates macrophage polarization and is required for proper granuloma formation during infections such as Q fever, thereby impacting bacterial clearance and tissue homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the tumorigenic context, Vanin‑1 has emerged as a modulator of neoplastic transformation. In adrenocortical cancer models driven by SF‑1 overexpression, genetic ablation of Vanin‑1 significantly alleviates neoplastic lesion severity, an effect that can be reversed by exogenous cysteamine."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, Vanin‑1 participates in cholesterol metabolism and inflammatory regulation within macrophage‐derived foam cells, thereby promoting atherosclerotic lesion development. Increased Vanin‑1 expression is associated with augmented cellular cholesterol accumulation and altered inflammatory mediator production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn autoimmune fibrotic disorders such as systemic sclerosis, dysregulation of the Vanin‑1/pantetheinase pathway contributes to fibrosis, vasculopathy, and autoimmunity. Elevated Vanin‑1 activity and its metabolite pantothenic acid correlate with disease severity, and inhibition of Vanin‑1 confers protection in experimental models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOn the analytical side, a highly sensitive bioluminogenic probe has been developed for in vivo detection of pantetheinase activity, facilitating real‑time monitoring of endogenous Vanin‑1 levels and advancing research into its diverse biological roles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic cancer, Vanin‑1 overexpression in malignant cells is implicated in paraneoplastic islet dysfunction. Cancer‑derived exosomes carrying Vanin‑1 disrupt normal islet function by inhibiting key metabolic regulators such as AMPK and Sirt1, leading to β‑cell dedifferentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther, in models of intrauterine growth retardation associated with asthma, upregulation of Vanin‑1 in bronchial epithelium activates the PI3K/Akt/NF‑κB signaling pathway, increasing oxidative stress and the production of inflammatory mediators that predispose to airway hyperresponsiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the setting of cancer chemoresistance, visualizing Vanin‑1 with a fluorescent probe has provided evidence that its inhibition can modulate glutathione synthesis; when combined with cisplatin, Vanin‑1 inhibition alters tumor cell response, underscoring its role in drug resistance mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, recent work highlights a potential role for Vanin‑1 in brown adipose tissue mitochondrial function and energy expenditure during obesity, suggesting that it may contribute to systemic metabolic regulation under conditions of overnutrition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these functions, studies in erythrocyte biology have linked reduced serum pantetheinase activity to shortened red blood cell lifespan and increased susceptibility to hemolytic stress, a finding that also correlates with complications during malaria infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, aberrant Vanin‑1 expression has been implicated in processes of ectopic bone formation and calcification observed in skeletal disorders, further illustrating its influence on chondrogenesis and osteoblastic function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is noteworthy that one study among the provided abstracts focused on a microRNA—miR‑203—in the modulation of lung injury in septic shock."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " However, none of these reports address the function of MIR548Y. Instead, the collective evidence centers on Vanin‑1, underscoring its diverse roles in oxidative stress regulation, inflammation, metabolism, tissue remodeling, and disease pathogenesis.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Davide Povero, Akiko Eguchi, Ingrid R Niesman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2004512"}], "href": "https://doi.org/10.1126/scisignal.2004512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24106341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24106341"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Florent Martin, Marie-France Penet, Fabrice Malergue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI19557"}], "href": "https://doi.org/10.1172/JCI19557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14966568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14966568"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "C Berruyer, F M Martin, R Castellano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.16.7214-7224.2004"}], "href": "https://doi.org/10.1128/MCB.24.16.7214-7224.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15282320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15282320"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Carole Berruyer, Laurent Pouyet, Virginie Millet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20061640"}], "href": "https://doi.org/10.1084/jem.20061640"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17145956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17145956"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Luana Di Leandro, Bruno Maras, M Eugenia Schininà, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cystamine restores GSTA3 levels in Vanin-1 null mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2007.12.015"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2007.12.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18206125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18206125"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Megan J Wilson, Pancharatnam Jeyasuria, Keith L Parker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M412806200"}], "href": "https://doi.org/10.1074/jbc.M412806200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15590666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15590666"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Siyu Chen, Wenxiang Zhang, Chunqi Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vanin-1 is a key activator for hepatic gluconeogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db13-0788"}], "href": "https://doi.org/10.2337/db13-0788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24550194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24550194"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Daniel W Ferreira, Michael J Goedken, Samuel Rommelaere, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2016.02.001"}], "href": "https://doi.org/10.1016/j.bbadis.2016.02.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26850476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26850476"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Janna A van Diepen, Patrick A Jansen, Dov B Ballak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep21906"}], "href": "https://doi.org/10.1038/srep21906"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26932716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26932716"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Soraya Meghari, Carole Berruyer, Hubert Lepidi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200636054"}], "href": "https://doi.org/10.1002/eji.200636054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17163446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17163446"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Perle Latre de Late, Abeer El Wakil, Marielle Jarjat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vanin-1 inactivation antagonizes the development of adrenocortical neoplasia in Sf-1 transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2014-1088"}], "href": "https://doi.org/10.1210/en.2014-1088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24712878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24712878"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yan-Wei Hu, Shao-Guo Wu, Jing-Jing Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M065565"}], "href": "https://doi.org/10.1194/jlr.M065565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27281478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27281478"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Niloufar Kavian, Souad Mehlal, Wioleta Marut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Imbalance of the Vanin-1 Pathway in Systemic Sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1502511"}], "href": "https://doi.org/10.4049/jimmunol.1502511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27647831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27647831"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yuxing Lin, Yuqi Gao, Zhao Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioluminescent Probe for Detection of Starvation-Induced Pantetheinase Upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anal Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.analchem.8b02266"}], "href": "https://doi.org/10.1021/acs.analchem.8b02266"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29976064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29976064"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wenjie Qin, Muxing Kang, Chao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VNN1 overexpression in pancreatic cancer cells inhibits paraneoplastic islet function by increasing oxidative stress and inducing β‑cell dedifferentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2023.8557"}], "href": "https://doi.org/10.3892/or.2023.8557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37114564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37114564"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yan Xing, Hongling Wei, Xiumei Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylated "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Vnn1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " at promoter regions induces asthma occurrence via the PI3K/Akt/NFκB-mediated inflammation in IUGR mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Open (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/bio.049106"}], "href": "https://doi.org/10.1242/bio.049106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32139393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32139393"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Pengpeng Lu, Caiyun Zhang, Lili Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role of Vanin-1 in Chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anal Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.analchem.1c02386"}], "href": "https://doi.org/10.1021/acs.analchem.1c02386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34275284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34275284"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Chen Sun, Jiaqi Liang, Jia Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Metab (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmet.2024.101884"}], "href": "https://doi.org/10.1016/j.molmet.2024.101884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38246587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38246587"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Samuel Rommelaere, Virginie Millet, Pascal Rihet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2015.07.011"}], "href": "https://doi.org/10.1016/j.ajpath.2015.07.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26343328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26343328"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kristen A Johnson, Wei Yao, Nancy E Lane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vanin-1 pantetheinase drives increased chondrogenic potential of mesenchymal precursors in ank/ank mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2008.070753"}], "href": "https://doi.org/10.2353/ajpath.2008.070753"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18187567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18187567"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Lan Ling, Hai-Tao Lu, Hai-Feng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-203 Acts as a Potent Suppressor in Septic Shock by Alleviating Lung Injury via Inhibition of VNN1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Blood Press Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000500484"}], "href": "https://doi.org/10.1159/000500484"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31340209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31340209"}]}]}]}