MIR550A2 Gene

HGNC Family Non-coding RNAs
Name microRNA 550a-2
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR550A2 (represented as miR-550a-3p in these studies) is a multifaceted regulator whose loss in breast cancer leads to deregulated Ras/ERK signaling. In this context, MIR550A2 directly targets and suppresses ERK1 and ERK2 expression, thereby weakening downstream oncogenic ERK/RSK cascades. Its progressive reduction during tumor initiation and progression is associated with increased cancer cell viability, migration, invasion, tumorigenesis, and metastasis, making its diminished levels a prognostic marker for poorer overall and disease‐free survival in breast cancer patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in oncogenesis, MIR550A2 has been implicated in the metabolic regulation of vitamin D in diabetes. In peripheral B cells, TNF‐α induces MIR550A2 expression, which in turn mediates chromatin remodeling at the cyp27b1 gene locus, leading to suppressed cyp27b1 expression. This suppression impairs the conversion of calcidiol to calcitriol, contributing to decreased bone mineral density observed in diabetic patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jar-Yi Ho, Ren-Jun Hsu, Chih-Hsi Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced miR-550a-3p leads to breast cancer initiation, growth, and metastasis by increasing levels of ERK1 and 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10793"}], "href": "https://doi.org/10.18632/oncotarget.10793"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27462780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27462780"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jinggui He, Xiyun Guo, Zhi-Qiang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Micro RNA-550a interferes with vitamin D metabolism in peripheral B cells of patients with diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Funct (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbf.3240"}], "href": "https://doi.org/10.1002/cbf.3240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27935135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27935135"}]}]}]}
Synonyms MIR550-2, MIRN550-2, MIR-550A-2, HSA-MIR-550A-2
NCBI Gene ID 693134
API
Download Associations
Predicted Functions View MIR550A2's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR550A2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR550A2's ARCHS4 Predicted Functions.

Functional Associations

MIR550A2 has 209 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR550A2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR550A2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR550A2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR550A2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR550A2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR550A2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR550A2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR550A2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR550A2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR550A2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR550A2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.