MIR551B Gene

HGNC Family Non-coding RNAs
Name microRNA 551b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR‐551b plays multifaceted, context‐dependent roles in human diseases. In several tumor types, including ovarian cancer, triple‐negative breast cancer, lung cancer, and papillary thyroid cancer, upregulation of specific miR‐551b isoforms (miR‐551b‐3p/‐5p) drives oncogenic processes. For example, in ovarian cancer stem cells, enhanced miR‐551b expression promotes proliferation, invasion, and chemoresistance by suppressing key tumor suppressors such as Foxo3 and TRIM31, while in triple‐negative breast cancer, genomic amplification leads to increased miR‐551b‐3p that translocates to the nucleus to activate STAT3‐mediated oncostatin signaling. In chemoresistant lung cancer cells, overexpressed miR‐551b contributes to acquired drug resistance by reducing catalase levels and potentiating EGFR‐Akt survival signaling, and in papillary thyroid cancer, high miR‐551b levels are associated with increased malignancy through inhibition of ERBB4."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, in several gastrointestinal and related malignancies miR‐551b appears to act as a tumor suppressor. In gastric cancer, diminished expression of miR‐551b correlates with epithelial–mesenchymal transition (EMT), metastasis, and poor prognosis, with its restoration inhibiting malignant behaviors via direct targeting of factors such as ERBB4 and TMPRSS4. Similarly, in cholangiocarcinoma, miR‐551b suppresses cell proliferation and induces apoptosis by downregulating Cyclin D1, while in gallbladder cancer, enforced miR‐551b expression reverses EMT by targeting H6PD. In colorectal cancer, studies have shown that miR‐551b (sequestered by oncogenic circRNAs in some settings) modulates cell cycle progression via CDK6, and exosomal delivery of miR‐551b from bone marrow–derived stromal cells can inhibit breast cancer cell growth and migration. Moreover, circulating levels of miR‐551b may serve as promising diagnostic biomarkers in gastric cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its direct roles in tumor biology, aberrant circulating levels of miR‐551b have been linked to inflammatory and premalignant conditions. Elevated miR‐551b‐5p levels have been observed in patients with acute pancreatitis, where they correlate with increased secretion of inflammatory cytokines, dysregulated autophagy, and greater disease severity. Similarly, altered miR‐551b expression has been reported in cervical intraepithelial neoplasia, further underscoring its potential as a non‐invasive biomarker for diagnostic and prognostic applications."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiuling Xu, Alexandria Wells, Mabel T Padilla, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "[Expression and clinical significance of microRNA-21-3p and microRNA-551-5p in patients with acute pancreatitis]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Wei Zhong Bing Ji Jiu Yi Xue (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn121430-20200116-00134"}], "href": "https://doi.org/10.3760/cma.j.cn121430-20200116-00134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32527354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32527354"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Huiping Wei, Hui Zhao, Dongliang Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-148a and miR-551b-5p regulate inflammatory responses via regulating autophagy in acute pancreatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2023.111438"}], "href": "https://doi.org/10.1016/j.intimp.2023.111438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38159552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38159552"}]}]}]}
Synonyms MIRN551B, MIR-551B
NCBI Gene ID 693136
API
Download Associations
Predicted Functions View MIR551B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR551B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR551B's ARCHS4 Predicted Functions.

Functional Associations

MIR551B has 214 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR551B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR551B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR551B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR551B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR551B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR551B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR551B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR551B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR551B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR551B from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR551B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR551B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR551B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR551B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR551B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.