{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed a tumor‐suppressive role for miR-557 in lung cancer. Reduced expression of miR-557 was observed in clinical lung cancer specimens and cell lines, where its overexpression decreased cell viability and invasion while promoting cell death through downregulation of lymphocyte enhancement factor 1 (via its 3' untranslated region). These findings indicate that miR-557 acts to inhibit lung cancer cell proliferation and invasion, suggesting its potential as a tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "MiR-557 also appears to play a significant role in immune thrombocytopenia (ITP). In experimental ITP models, enhanced miR-557 expression was associated with impaired proliferation and maturation of thrombopoietin-induced megakaryocytes, along with increased apoptotic signaling. Conversely, inhibition of miR-557 improved the physiological function of megakaryocytes, increased platelet counts, modulated apoptosis-related gene expression, and activated the Akt/ERK signaling pathway, collectively ameliorating ITP symptoms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Moreover, in hepatocellular carcinoma (HCC), miR-557 is down-regulated in tumor tissues and cell lines and is linked to tumor recurrence and metastasis. Restoration of miR-557 levels inhibited HCC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition by directly targeting RAB10 and suppressing the Wnt/β-catenin signaling cascade. This evidence reinforces the concept that miR-557 functions as a tumor suppressor across diverse cancer types by modulating key oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiayong Qiu, Yingying Hao, Shenshen Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-557 works as a tumor suppressor in human lung cancers by negatively regulating LEF1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317709467"}], "href": "https://doi.org/10.1177/1010428317709467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28639890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28639890"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Wang, Yujie Guo, Xiaolei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role and mechanism of miR-557 in inhibiting the differentiation and maturation of megakaryocytes in immune thrombocytopenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2021.1884783"}], "href": "https://doi.org/10.1080/15476286.2021.1884783"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33586614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33586614"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoye Cheng, Can Wu, Haocheng Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-557 inhibits hepatocellular carcinoma progression through Wnt/β-catenin signaling pathway by targeting RAB10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.205554"}], "href": "https://doi.org/10.18632/aging.205554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38364252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38364252"}]}]}]}