{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into the molecular underpinnings of sporadic amyotrophic lateral sclerosis (sALS) have revealed that altered microRNA profiles may significantly contribute to disease pathology. In particular, the levels of miR-5572 are notably elevated in the spinal cords of sALS patients, concurrent with a reduction in miR-139-5p, suggesting a dysregulation of miRNA homeostasis in neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Dissecting the functional impact of miR-5572, researchers employed bioinformatics tools, notably TargetScan, to predict that SLC30A3, a zinc transporter previously observed at reduced levels in sALS patients, is one of its targets. Experimental validation confirmed that miR-5572 directly regulates SLC30A3 expression, thereby reinforcing the notion that increased miR-5572 may contribute to the diminished SLC30A3 levels seen in sALS."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Overall, these findings highlight the novel role of miR-5572 as a modulator of SLC30A3, implicating it as a potential key player in sALS pathogenesis. As miR-5572 appears to drive down the expression of a gene essential for zinc homeostasis, its dysregulation might exacerbate neurodegenerative processes, opening avenues for further research into miRNA-based therapeutic strategies in ALS."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hisaka Kurita, Saori Yabe, Tomoyuki Ueda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-5572 Is a Novel MicroRNA-Regulating "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SLC30A3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in Sporadic Amyotrophic Lateral Sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21124482"}], "href": "https://doi.org/10.3390/ijms21124482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32599739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32599739"}]}]}]}