{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations in oral cancer have uncovered a pivotal role for miR‑5580‑3p as a tumor suppressor via direct regulation of laminin subunit γ2 (LAMC2). Bioinformatics analyses identified a unique miR‑5580‑3p/LAMC2 interactome, and subsequent experiments revealed that miR‑5580‑3p is significantly downregulated in oral cancer tissues and cell lines, whereas LAMC2 is concomitantly upregulated. Functional assays demonstrated that re‑expression of miR‑5580‑3p inhibits cell viability, proliferation, and migration by directly targeting LAMC2 mRNA, as confirmed by luciferase reporter assays. These findings suggest that the miR‑5580‑3p/LAMC2 axis plays a crucial role in the malignant progression of oral cancer and may serve as a promising biomarker and therapeutic target for future diagnosis and treatment strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rong Fang, Qian Lu, Bo Xu "}, {"type": "b", "children": [{"type": "t", "text": "hsa‑miR‑5580‑3p inhibits oral cancer cell viability, proliferation and migration by suppressing LAMC2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12092"}], "href": "https://doi.org/10.3892/mmr.2021.12092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33880581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33880581"}]}]}]}