{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn one study, a FOXJ1‐dependent genetic programme was elucidated that directs proper formation and function of motile cilia during spermiogenesis. The investigation identified a novel FOXJ1 target, Cfap157, whose protein product localizes at basal bodies and interacts with cytoskeletal components to ensure the correct ultrastructural formation of sperm flagella – a process essential for normal sperm motility. Although MIR5585 is not directly discussed in this research, the study contributes to our broader understanding of the regulation of motile cilia functions and the genetic networks that might also be modulated by regulatory RNAs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA separate study focusing on miRNA:mRNA interactions provided insights where miR-5585-3p, a specific variant of MIR5585, was found to bind with high affinity to the mRNAs of 655 genes. This miRNA exhibits binding sites distributed across both coding sequences and untranslated regions, often with multiple binding sites per transcript, suggesting its potential role as a broad regulator of gene expression that may impact diverse cellular pathways through coordinated post-transcriptional control."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marina Weidemann, Karin Schuster-Gossler, Michael Stauber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.139626"}], "href": "https://doi.org/10.1242/dev.139626"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27965440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27965440"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anatoly Ivashchenko, Olga Berillo, Anna Pyrkova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The properties of binding sites of miR-619-5p, miR-5095, miR-5096, and miR-5585-3p in the mRNAs of human genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/720715"}], "href": "https://doi.org/10.1155/2014/720715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25162022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25162022"}]}]}]}