{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into lung adenocarcinoma (LAD) have identified WNT5B as an oncogenic factor whose high expression correlates with lymph node metastasis, advanced TNM stage, and poor prognosis. In this context, miR-5587-3p was discovered to serve as a negative upstream regulator of WNT5B, providing a critical checkpoint in the oncogenic signaling cascade within LAD cells. The study suggests that the downregulation of WNT5B by miR-5587-3p contributes to the suppression of cellular proliferation and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Disruption of the WNT5B pathway through the intervention of miR-5587-3p interferes with key cellular processes, particularly the G1/S cell-cycle transition and amino acid metabolism, which are essential for tumor cell growth and survival. By acting as a molecular brake, miR-5587-3p limits the proliferative capacity of LAD cells, thereby highlighting its potential role as a tumor suppressor in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "These findings not only emphasize the oncogenic role of WNT5B in lung adenocarcinoma but also introduce miR-5587-3p as a promising therapeutic target. Targeting the miR-5587-3p/WNT5B axis may offer new avenues for the development of treatments tailored to patients with high WNT5B expression, ultimately aiming to improve clinical outcomes in LAD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qun Zhang, Hang Fan, Hongda Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT5B exerts oncogenic effects and is negatively regulated by miR-5587-3p in lung adenocarcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-019-1071-4"}], "href": "https://doi.org/10.1038/s41388-019-1071-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31666682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31666682"}]}]}]}