{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified a role for miR-559 in the post‐transcriptional regulation of oncogenes. In one investigation, bioinformatic and experimental analyses demonstrated that miR-559 can bind to the 3′-untranslated region of ERBB2 mRNA. Notably, when co-expressed with miR-548d-3p, miR-559 cooperatively repressed the translation of ERBB2, suggesting that combined miRNA regulation could be leveraged in ERBB2-targeted therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn another study, genetic analysis of miR-559 revealed that a single nucleotide polymorphism, rs58450758, can alter its secondary structure and create novel DICER processing sites. The presence of this variant was significantly associated with an increased risk of breast cancer, indicating that alterations in the miR-559 sequence may modify its regulatory function in pathways crucial for tumor suppression and oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, while recent efforts have expanded the scope of noncoding RNA investigations in hepatocellular carcinoma—such as studies on LINC01287—direct mechanistic connections between miR-559 and hepatocellular carcinoma have not been explicitly defined. This underscores the need for further research to elucidate whether miR-559 may also participate in the complex regulatory networks impacting liver cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hong Chen, Jian Guo Sun, Xue-Wu Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preliminary validation of ERBB2 expression regulated by miR-548d-3p and miR-559."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.05.113"}], "href": "https://doi.org/10.1016/j.bbrc.2009.05.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19486885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19486885"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "F Bahreini, S Ramezani, S S Shahangian, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-559"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " polymorphism "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "rs58450758"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " is linked to breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Biomed Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09674845.2019.1683309"}], "href": "https://doi.org/10.1080/09674845.2019.1683309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31642395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31642395"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Y-B Song, Z Yu, A-Q Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proliferation and migration of hepatocellular carcinoma are accelerated by LINC01287 via the miR-559/TCF12 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202006_21496"}], "href": "https://doi.org/10.26355/eurrev_202006_21496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32572916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32572916"}]}]}]}