{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a recent study, exposure of adipose tissue-derived stem cells (ADSCs) to advanced glycation end products (AGEs) was shown to trigger the AGEs/AGER interaction, leading to increased production of reactive oxygen species (ROS) and the induction of apoptosis. Notably, the study found that AGEs treatment downregulated miR-5591-5p levels, suggesting that this microRNA is sensitive to diabetic stress conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic investigations revealed that miR-5591-5p directly targets the AGER receptor mRNA, thereby mitigating the deleterious effects of the AGEs/AGER axis. By inhibiting this pathway, miR-5591-5p effectively suppresses ROS generation as well as the c-jun N-terminal kinase (JNK) signaling cascade, which is implicated in mediating apoptotic cell death in ADSCs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, restoration of miR-5591-5p levels in ADSCs not only enhanced cell survival in vitro but also significantly improved their capacity to promote cutaneous wound repair in diabetic models. This protective, pro-healing role underscores the therapeutic potential of miR-5591-5p in modulating the cellular response under diabetic conditions by counteracting AGEs-induced oxidative stress and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiang Li, Sizhan Xia, Yating Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-5591-5p regulates the effect of ADSCs in repairing diabetic wound via targeting AGEs/AGER/JNK signaling axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0615-9"}], "href": "https://doi.org/10.1038/s41419-018-0615-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29752466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29752466"}]}]}]}