{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings have identified miR562 as a novel microRNA regulated by Annexin 1 in breast cancer cells that directly targets components of the canonical NF-κB pathway. In MCF7 cells, miR562 reduces expression of NF-κB1 (p105) by binding its 3′ untranslated region, thereby suppressing NF-κB signaling. This downregulation has functional consequences, as overexpression of miR562 in these cells was shown to inhibit wound healing while concurrently enhancing the secretion of angiogenic factors that promote endothelial tube formation—a phenotype that underscores its potential role in modulating tumor-induced angiogenesis and metastasis. Moreover, the reversal of these effects upon Annexin 1 overexpression further substantiates a regulatory axis in which miR562 fine-tunes NF-κB activity, suggesting that modulation of miR562 levels could represent a promising therapeutic strategy in breast cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Durkeshwari Anbalagan, Gracemary Yap, Yi Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Annexin-A1 regulates microRNA-26b* and microRNA-562 to directly target NF-κB and angiogenesis in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0114507"}], "href": "https://doi.org/10.1371/journal.pone.0114507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25536365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25536365"}]}]}]}