{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNAs are emerging as pivotal regulators of cancer progression, and miR‐567 has been implicated as a potential tumor suppressor in diverse malignancies. In breast cancer, for instance, Hsa‐miR‐567 is markedly downregulated in tumors with poorer prognoses, and this decrease correlates with enhanced cell proliferation and migration through deregulated expression of its target, KPNA4. These findings underscore its role in modulating tumor aggressiveness and suggest that restoration of miR‐567 levels might offer therapeutic benefits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, investigations are underway to elucidate the biological impact of miR‐567 on tumorigenesis and chemoresistance. The current study aims to unravel how alterations in miR‐567 expression may influence not only the growth of gastric tumors but also their sensitivity to chemotherapeutic agents, potentially offering insights into overcoming chemoresistance in this prevalent cancer type."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in renal cell carcinoma, the regulatory network involving miR‐567 has been further clarified. Silencing of the oncogenic circular RNA circNUP98 results in upregulation of miR‐567, which in turn leads to the downregulation of PRDX3—a change associated with inhibited RCC progression. This STAT3/circNUP98/miR‐567/PRDX3 axis highlights a novel mechanism by which miR‐567 contributes to suppressing tumor development and provides an additional avenue for targeted intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gloria Bertoli, Claudia Cava, Cecilia Diceglie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-567 dysregulation contributes to carcinogenesis of breast cancer, targeting tumor cell proliferation, and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-016-4079-2"}], "href": "https://doi.org/10.1007/s10549-016-4079-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28000015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28000015"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Feifei Zhang, Kaitao Li, Xueqing Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A miR-567-PIK3AP1-PI3K/AKT-c-Myc feedback loop regulates tumour growth and chemoresistance in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2019.05.003"}], "href": "https://doi.org/10.1016/j.ebiom.2019.05.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31078520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31078520"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rui Yu, Jie Yao, Yu Ren "}, {"type": "b", "children": [{"type": "t", "text": "A novel circRNA, circNUP98, a potential biomarker, acted as an oncogene via the miR-567/ PRDX3 axis in renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15629"}], "href": "https://doi.org/10.1111/jcmm.15629"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32729669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32729669"}]}]}]}