MIR568 Gene

HGNC Family Non-coding RNAs
Name microRNA 568
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn CD4(+) T cells, MIR568 functions as a negative regulator of activation and differentiation. Its expression decreases upon T‐cell activation, and forced over‐expression using miR-568 mimics attenuates key activation markers (CD25, CD69, CD154), diminishes IL-2 production, and limits cell proliferation. In regulatory T cells (Treg), elevated levels of MIR568 also suppress NFAT5 expression, resulting in reduced production of immunosuppressive cytokines (TGF-β and IL-10), impaired Treg differentiation, and weakened suppression of effector cells. These findings indicate that MIR568 modulates both the activation of conventional CD4(+) T cells and the regulatory functions of Treg cells, suggesting its potential as a target for inflammatory and autoimmune disease treatments."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Disruptive inflammation in the lung endothelium associated with conditions such as ARDS and VILI is also subject to posttranscriptional control by MIR568. In human lung endothelial cells, MIR568 binds to the 3′-UTR of the proinflammatory molecule PBEF/NAMPT, thereby attenuating its transcriptional and translational upregulation in response to bioactive agonists like cyclic stretch and LPS. This inhibitory modulation of PBEF/NAMPT by MIR568 suggests a therapeutic avenue for reducing inflammatory lung injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Li, Ling-bo Kong, Jun-Tang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-568 inhibits the activation and function of CD4⁺ T cells and Treg cells by targeting NFAT5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/intimm/dxt065"}], "href": "https://doi.org/10.1093/intimm/dxt065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24355664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24355664"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Djanybek M Adyshev, Venkateswaran Ramamoorthi Elangovan, Nurgul Moldobaeva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanical stress induces pre-B-cell colony-enhancing factor/NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2013-0292OC"}], "href": "https://doi.org/10.1165/rcmb.2013-0292OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24053186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24053186"}]}]}]}
Synonyms MIRN568, HSA-MIR-568
NCBI Gene ID 693153
API
Download Associations
Predicted Functions View MIR568's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR568's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR568's ARCHS4 Predicted Functions.

Functional Associations

MIR568 has 815 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.

Click the + buttons to view associations for MIR568 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR568 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR568 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR568 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR568 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR568 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR568 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR568 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing MIR568 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR568 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR568 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR568 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR568 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR568 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR568 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR568 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR568 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR568 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.