| Name | microRNA 5692c-1 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study provided (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "investigated the impact of limitin—an interferon-like cytokine—on B lymphopoiesis by engaging the interferon‐α/β receptor and triggering intracellular signal transduction cascades. Although the research offers crucial insights into how limitin suppresses B cell development via these pathways, it does not address or describe any specific functional role for MIR5692C1. Consequently, based on the available information in this abstract, MIR5692C1 is not implicated in the described signaling events, and its function remains to be elucidated in further studies.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kenichi Aoki, Kazuya Shimoda, Kenji Oritani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Hematol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exphem.2003.08.011"}], "href": "https://doi.org/10.1016/j.exphem.2003.08.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14662340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14662340"}]}]}]}
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| NCBI Gene ID | 100847082 |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR5692C1 has 109 functional associations with biological entities spanning 1 categories (cell line, cell type or tissue) extracted from 2 datasets.
Click the + buttons to view associations for MIR5692C1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR5692C1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR5692C1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |