{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nExosomes derived from pancreatic stellate cells (PSCs) play a critical role in the pancreatic cancer microenvironment by delivering miR-5703 to cancer cells, thereby enhancing their proliferation. Specifically, miR-5703 acts as a key proliferative driver by binding to the 3' untranslated region of CMTM4 and downregulating its expression. This suppression of CMTM4 facilitates activation of the PI3K/Akt signaling cascade through PAK4, ultimately promoting cell proliferation. Conversely, inhibition of miR-5703 or overexpression of CMTM4 can mitigate this proliferative effect, suggesting a promising avenue for therapeutic intervention in pancreatic cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mingzhe Li, Huahu Guo, Qi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2020.06.009"}], "href": "https://doi.org/10.1016/j.canlet.2020.06.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32585413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32585413"}]}]}]}