{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA comprehensive review of the provided literature reveals that the studies focus on diverse aspects of cellular metabolism, oncogenesis, and immune responses—involving enzymes such as PYCR1/PYCR2 in proline biosynthesis and their roles in conditions ranging from Cutis Laxa and leukodystrophy to myocardial infarction and cancer progression, as well as on non‐coding RNAs and micropeptides in cancer and asthma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, none of the abstracts provide any reference, data, or analysis regarding the function or biological significance of MIR5705. Consequently, while these studies offer insights into metabolic enzymes, signaling pathways, and regulatory non-coding elements in various disease models, they do not address MIR5705, leaving its role undetermined in the contexts examined."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt follows that further research specifically targeting MIR5705 is required to elucidate its function, any potential regulatory mechanisms it may participate in, and its possible involvement in disease processes. Meanwhile, the current body of work underscores the multifaceted regulation of cellular metabolism and signaling through other molecules, even as the role of MIR5705 remains to be clarified."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Morgane G Stum, Abigail L D Tadenev, Kevin L Seburn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis of Pycr1 and Pycr2 in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genetics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/genetics/iyab048"}], "href": "https://doi.org/10.1093/genetics/iyab048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33734376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33734376"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhuo Li, Ying Jiang, Jian Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomes from PYCR1 knockdown bone marrow mesenchymal stem inhibits aerobic glycolysis and the growth of bladder cancer cells via regulation of the EGFR/PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2023.5532"}], "href": "https://doi.org/10.3892/ijo.2023.5532"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37293856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37293856"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sapna Iyer, Min-Jung Park, David Moons, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.12.039"}], "href": "https://doi.org/10.1016/j.bbrc.2016.12.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27939882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27939882"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhimin Xue, Yiwen Pan, Xugang Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metabolomic and transcriptomic studies of improvements in myocardial infarction due to Pycr1 deletion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.17637"}], "href": "https://doi.org/10.1111/jcmm.17637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36495058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36495058"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hong Wang, Dongsheng He "}, {"type": "b", "children": [{"type": "t", "text": "LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18-610"}], "href": "https://doi.org/10.14670/HH-18-610"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36994814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36994814"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhengxia Wang, Xinyu Jia, Wei Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A micropeptide TREMP encoded by lincR-PPP2R5C promotes Th2 cell differentiation by interacting with PYCR1 in allergic airway inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergol Int (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.alit.2024.04.004"}], "href": "https://doi.org/10.1016/j.alit.2024.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39025723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39025723"}]}]}]}