{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence has begun to implicate microRNA MIR5708 in the genetic architecture underlying chronic obstructive pulmonary disease (COPD). In a study specifically designed to evaluate genetic polymorphisms, variations in MIR5708 (evaluated in parallel with MIR1208) were analyzed for their impact on COPD risk—a disorder characterized by reduced airflow and complex genetic and environmental contributions. The findings from this investigation suggest that specific allelic variants of MIR5708 may alter its regulatory function, potentially affecting the expression of target genes involved in lung homeostasis and inflammatory response, thereby contributing to individual susceptibility to COPD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Zhou, F Bai, X Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms in MIR1208 and MIR5708 are associated with susceptibility to COPD in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pulmonology (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pulmoe.2021.07.004"}], "href": "https://doi.org/10.1016/j.pulmoe.2021.07.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36115827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36115827"}]}]}]}