{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-572 has emerged as an oncogenic microRNA in several malignancies. In ovarian cancer, for instance, elevated miR-572 promotes cell cycle progression and tumorigenicity by directly suppressing the expression of important regulators such as SOCS1 and p21, thereby correlating with poorer overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similar oncogenic functions have been reported in hepatocellular carcinoma, where upregulated miR-572 inhibits apoptosis and enhances cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In renal cell carcinoma, increased miR-572 levels drive proliferation and mobility while inhibiting early apoptosis, with higher expression portending a worse prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, preliminary findings in Wilms’ tumor suggest that miR-572 may influence metastasis and epithelial‐mesenchymal transition, though its precise effects remain to be fully elucidated"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and similar proliferation and migration–promoting roles have been observed in non–small cell lung cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cancer, miR-572 is involved in neurological processes. In multiple sclerosis, deregulation of miR-572 has been linked to its modulation of neural cell adhesion molecule 1 (NCAM1), a glycoprotein important for central nervous system repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In the setting of post–operative cognitive dysfunction, reduced circulating miR-572 levels have been associated with increased NCAM1 expression in hippocampal neurons and subsequent improvements in cognitive function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Complementary studies in a human oligodendroglial cell model have confirmed that miR-572 directly regulates NCAM1 expression, reinforcing its potential as a biomarker in neurological disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, investigations on neural cell lines have demonstrated that pharmacological agents such as fluoxetine can upregulate miR-572 expression in undifferentiated neural cells, suggesting that miR-572 may participate in the neurodevelopmental effects of psychotropic drugs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xin Zhang, Junling Liu, Dan Zang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "microRNA‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6649"}], "href": "https://doi.org/10.3892/or.2018.6649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30132566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30132566"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "C Zhang, G-Q Lv, L-F Cui, et al. 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