MIR577 Gene

HGNC Family Non-coding RNAs
Name microRNA 577
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In colorectal cancer, miR-577 targets heat shock protein 27 (HSP27), and in esophageal squamous cell carcinoma it binds to the 3' untranslated region of TSGA10, thereby influencing the G1-S phase transition. In addition, miR-577 suppresses the Wnt/β-catenin pathway by targeting components such as WNT2B (in osteosarcoma and non-small cell lung cancer) and the upstream co-receptors like LRP6 (in glioblastoma). Other studies have shown that miR-577 directly downregulates HOXA1 in hepatocellular and lung cancers and targets EIF5A2 to inhibit epithelial-mesenchymal transition and drug resistance in nasopharyngeal carcinoma. These interactions are often orchestrated by upstream non-coding RNAs that act as sponges, including lncRNAs (e.g., DANCR in both colorectal cancer and osteoarthritis, lnc-SNHG1 in osteosarcoma, DSCAM-AS1 in lung cancer) and circular RNAs (e.g., circ_0008450 in nasopharyngeal carcinoma), which further modulate its activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, restoration of miR-577 expression in various cancer cell models suppresses malignant behaviors by reducing proliferation, invasion, and epithelial-mesenchymal transition while enhancing apoptosis and chemosensitivity. In addition, in diffuse large B-cell lymphoma, the oncogenic lncRNA TRIM52-AS1 promotes tumor progression by sponging miR-577 to stabilize TRIM52 mRNA, further underscoring miR-577’s pivotal role as a negative regulator of tumor-promoting pathways. These findings support the potential therapeutic value of strategies aimed at restoring miR-577 function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiang Yuan, Jiangtu He, Fenyong Sun, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "microRNA-577 suppresses tumor growth and enhances chemosensitivity in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.21888"}], "href": "https://doi.org/10.1002/jbt.21888"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28150434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28150434"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "K-C Xue, D-D Hu, L Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-577 inhibits papillary thyroid carcinoma cell proliferation, migration and invasion by targeting SphK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28975989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28975989"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhe Jiang, Chunshan Jiang, Jinnv Fang "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.11.012"}], "href": "https://doi.org/10.1016/j.bbrc.2017.11.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29108989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29108989"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chonggao Yin, Qingjie Mou, Xinting Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-577 suppresses epithelial-mesenchymal transition and metastasis of breast cancer by targeting Rab25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.12612"}], "href": "https://doi.org/10.1111/1759-7714.12612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29524309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29524309"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaochen Fan, Jishan Yuan, Jun Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-protein coding RNA DANCR functions as a competing endogenous RNA to regulate osteoarthritis progression via miR-577/SphK2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.130"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29678573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29678573"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shaoshan Han, Zhikui Liu, Yufeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6388"}], "href": "https://doi.org/10.3892/or.2018.6388"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29693150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29693150"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yong Wang, Zhi Lu, Ningnin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR-577 sponging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-018-0082-5"}], "href": "https://doi.org/10.1038/s12276-018-0082-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29717105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29717105"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Bin Wang, Liwei Sun, Jinduo Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt/β-catenin pathway in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9279"}], "href": "https://doi.org/10.3892/mmr.2018.9279"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30015869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30015869"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lan Men, Dandan Nie, Haiying Nie "}, {"type": "b", "children": [{"type": "t", "text": "microRNA‑577 inhibits cell proliferation and invasion in non‑small cell lung cancer by directly targeting homeobox A1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.9804"}], "href": "https://doi.org/10.3892/mmr.2019.9804"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30628697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30628697"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hongjuan Wei, Deshui Liu, Jia Sun, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate diffuse large B cell lymphoma progression via increasing TRIM52 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-022-00725-1"}], "href": "https://doi.org/10.1007/s13577-022-00725-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35676608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35676608"}]}]}]}
Synonyms MIRN577, HSA-MIR-577, MIR-577
NCBI Gene ID 693162
API
Download Associations
Predicted Functions View MIR577's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR577's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR577's ARCHS4 Predicted Functions.

Functional Associations

MIR577 has 234 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR577 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR577 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR577 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR577 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR577 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR577 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR577 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of MIR577 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR577 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR577 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR577 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR577 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.