{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR-5787 is a recently identified microRNA that plays multifaceted roles in cellular regulation. Initially characterized in human mesenchymal stem cells and found to be upregulated in senescent fibroblasts, miR-5787 represses cell proliferation in part by directly targeting eukaryotic translation initiation factor 5 (eIF5), thereby modulating protein synthesis and growth control."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In an independent study of ischemic cerebral infarction, reduced levels of miR-5787 were observed in peripheral blood mononuclear cells, where its downregulation correlated inversely with the expression of inflammatory cytokines IL-6 and TNF-α as well as Toll-like receptor 4 (TLR4). Functional analysis revealed that miR-5787 targets TLR4, consequently inhibiting macrophage proliferation, migration, and NF-κB-mediated inflammatory pathways, suggesting a protective role in the modulation of inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, the differential expression of miR-5787 has been explored in the context of acute graft-versus-host disease (aGVHD). In this study, plasma levels of miR-5787 were significantly downregulated in aGVHD patients compared to non-GVHD controls, underscoring its potential utility as a noninvasive diagnostic biomarker. In silico analyses indicated that miR-5787 is involved in the regulation of immune functions and inflammatory processes, positioning it as a promising candidate for both early detection and therapeutic intervention in aGVHD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hanna Yoo, Jung Ki Yoo, Jimin Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The hsa-miR-5787 represses cellular growth by targeting eukaryotic translation initiation factor 5 (eIF5) in fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.10.103"}], "href": "https://doi.org/10.1016/j.bbrc.2011.10.103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22062548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22062548"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhicheng Bao, Shuguang Zhang, Xiaoliang Li "}, {"type": "b", "children": [{"type": "t", "text": "MiR-5787 Attenuates Macrophages-Mediated Inflammation by Targeting TLR4/NF-κB in Ischemic Cerebral Infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromolecular Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12017-020-08628-w"}], "href": "https://doi.org/10.1007/s12017-020-08628-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33165670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33165670"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jamshid Motaei, Mohammad Amin Kerachian, Seied Asadollah Mousavi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-455-3p, miR-5787, and miR-548a-3p as potential noninvasive biomarkers in the diagnosis of acute graft-versus-host disease: a validation study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hematol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00277-021-04573-1"}], "href": "https://doi.org/10.1007/s00277-021-04573-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34247256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34247256"}]}]}]}