MIR580 Gene

HGNC Family Non-coding RNAs
Name microRNA 580
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have elucidated the critical role of miR‑580 in modulating transcription factors involved in tumor progression. In breast cancer models, miR‑580, together with RNA‑binding proteins CPEB1 and CPEB2, acts as a negative regulator of TWIST1 expression by binding its 3′UTR, thereby curtailing epithelial–mesenchymal transition and early carcinogenic events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma and other malignancies, miR‑580 is found to be functionally inactivated through sequestration by various non‑coding RNAs. For instance, hsa_circ_0110102 was shown to sponge miR‑580‑5p, relieving its repression on PPARα and ultimately reducing CCL2 secretion and the downstream COX‑2/PGE2 signaling in the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in osteosarcoma cells, circRAB3IP binds miR‑580‑3p to derepress TWIST1 expression, thereby promoting cellular proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In acute myeloid leukemia, the long non‑coding RNA SATB1‑AS1 serves as a competing endogenous RNA, sponging miR‑580 and consequently upregulating OAS2, an event that modulates drug sensitivity through the GSK‑3β/β‑catenin axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gastric carcinoma, the tumor‑suppressive linc‑ROR is transcriptionally activated by SOX2 and exerts its inhibitory function, in part, by binding miR‑580‑3p; this interaction results in an increased expression of ANXA10, thereby attenuating cell proliferation, migration, and invasion and promoting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M-L Nairismägi, A Vislovukh, Q Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.650"}], "href": "https://doi.org/10.1038/onc.2011.650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22266852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22266852"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xinxing Wang, Wei Sheng, Tao Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARα/CCL2 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202900"}], "href": "https://doi.org/10.18632/aging.202900"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33891564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33891564"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guojun Tang, Linghua Liu, Zhihong Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRAB3IP upregulates twist family BHLH transcription factor (TWIST1) to promote osteosarcoma progression by sponging miR-580-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1948487"}], "href": "https://doi.org/10.1080/21655979.2021.1948487"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34224315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34224315"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hong Zhou, Xiaofeng Jia, Fan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1971508"}], "href": "https://doi.org/10.1080/21655979.2021.1971508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34516354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34516354"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Liping Bai, Yifan Zhuang, Jun Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX2-Induced Linc-ROR Upregulation Inhibits Gastric Carcinoma Cell Proliferation and Metastasis Via the miR-580-3p/ANXA10 Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-022-10300-w"}], "href": "https://doi.org/10.1007/s10528-022-10300-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36451051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36451051"}]}]}]}
Synonyms MIRN580, HSA-MIR-580
NCBI Gene ID 693165
API
Download Associations
Predicted Functions View MIR580's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR580's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR580's ARCHS4 Predicted Functions.

Functional Associations

MIR580 has 298 functional associations with biological entities spanning 5 categories (molecular profile, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 16 datasets.

Click the + buttons to view associations for MIR580 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR580 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR580 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR580 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR580 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with MIR580 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR580 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR580 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR580 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR580 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR580 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR580 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR580 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR580 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR580 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR580 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR580 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.