{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐581 has been shown to modulate key oncogenic processes in hepatocellular carcinoma. In one study, miR-581 was found to promote hepatitis B virus surface antigen (HBsAg) expression by targeting and downregulating both Dicer and EDEM1. This regulation appears to increase HBsAg secretion and enhance cell proliferation, suggesting that altered miR-581 levels during hepatocarcinogenesis could contribute to disease progression by impacting viral antigen expression and cellular growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn colorectal cancer, miR-581 has emerged as a regulator of metastasis. It directly targets SMAD7 to modulate the TGFβ signaling pathway, thereby influencing epithelial-to-mesenchymal transition, invasion, and cell survival. Functional assays indicated that inhibition of miR-581 suppresses cell proliferation and induces apoptosis, further underlining its potential role as a driver of metastatic behavior in colorectal tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in another investigation of hepatocellular carcinoma, miR-581 was implicated in tumor progression through a competing endogenous RNA network. Here, the long non-coding RNA lnc-COX7C-5 serves as a molecular sponge for miR-581, thereby modulating the expression of the downstream target ZEB2. This regulatory axis was associated with enhanced proliferation, migration, invasion, and even lung metastasis in vivo, suggesting that the lnc-COX7C-5/miR-581/ZEB2 pathway may represent a promising therapeutic target in HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yu-Qun Wang, Yong-Feng Ren, Yi-Jiang Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-581 promotes hepatitis B virus surface antigen expression by targeting Dicer and EDEM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgu128"}], "href": "https://doi.org/10.1093/carcin/bgu128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24913918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24913918"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaojuan Zhao, Shuzhen Liu, Bianbian Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-581/SMAD7 Axis Contributes to Colorectal Cancer Metastasis: A Bioinformatic and Experimental Validation-Based Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21186499"}], "href": "https://doi.org/10.3390/ijms21186499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32899503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32899503"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yantin Lin, Fei Wang, Yue Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA COX7C-5 promotes hepatocellular carcinoma progression via miR-581/ZEB2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2022.110501"}], "href": "https://doi.org/10.1016/j.cellsig.2022.110501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36273755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36273755"}]}]}]}