MIR583 Gene

HGNC Family Non-coding RNAs
Name microRNA 583
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have uncovered distinct roles for MIR583 in modulating key cellular pathways in different disease contexts. In intervertebral disc degeneration (IDD), the circular RNA FAM169A (circ‐FAM169A) was found to sequester MIR583 in nucleus pulposus cells, thereby relieving its suppression on BTRC—a protein known to induce NF-κB signaling. The subsequent upregulation of BTRC promotes extracellular matrix catabolism and suppresses anabolic processes, contributing to the degenerative process in disc tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn contrast, in prostate cancer, MIR583 appears to function as a tumor suppressor. The downregulation of MIR583 in prostate cancer tissues correlates with increased expression of its target gene JAK1, which in turn augments the activation of the STAT3 pathway. Experimentally, restoring MIR583 levels inhibited cell proliferation and invasion by decreasing both JAK1 and phosphorylated STAT3 levels, underscoring its potential as a therapeutic target in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Guo, Kun Mu, Bin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2543-8"}], "href": "https://doi.org/10.1038/s41419-020-2543-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32366862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32366862"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhongyi Li, Jianheng Chen "}, {"type": "b", "children": [{"type": "t", "text": "miR‑583 inhibits the proliferation and invasion of prostate cancer cells by targeting JAK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.11838"}], "href": "https://doi.org/10.3892/mmr.2021.11838"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33495837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33495837"}]}]}]}
Synonyms MIRN583, HSA-MIR-583
NCBI Gene ID 693168
API
Download Associations
Predicted Functions View MIR583's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR583's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR583's ARCHS4 Predicted Functions.

Functional Associations

MIR583 has 414 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR583 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR583 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR583 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR583 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR583 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR583 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR583 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR583 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR583 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR583 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR583 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR583 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.