{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn colorectal cancer, miR-587 has emerged as a key regulator of chemoresistance and metastatic behavior. Specifically, miR-587 confers resistance to 5‐fluorouracil (5‐FU)–induced apoptosis by downregulating PPP2R1B, which in turn enhances AKT phosphorylation and increases XIAP expression, thereby blunting the cytotoxic effects of chemotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, a circular RNA—hsa_circ_0001178—functions as a competing endogenous RNA (ceRNA) that sequesters miR-587 (along with miR-382 and miR-616) to promote ZEB1 expression and facilitate epithelial-to-mesenchymal transition, ultimately contributing to metastatic dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer, miR-587 also participates in metabolic regulation and adipocyte differentiation. Alterations in serum miR-587 levels have been correlated with metabolic syndrome, suggesting its potential utility as a biomarker for systemic metabolic disturbances."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In visceral adipose tissue, the long non-coding RNA RP11-142A22.4 modulates preadipocyte differentiation via a miR-587/Wnt5β signaling axis, where increased miR-587 expression impedes adipocyte maturation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a wide spectrum of malignancies, miR-587 functions predominantly as an oncogenic factor. Aberrant miR-587 expression has been observed in hepatocellular carcinoma (HCC)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and in non-small-cell lung carcinoma (NSCLC), miR-587 drives malignant cell proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In HCC, upregulation mediated by lncRNA PANTR1 further promotes increased BCL2A1 expression and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In lung adenocarcinoma, circZMYM4 has been shown to regulate miR-587 signaling to control the expression of the tumor suppressor ODAM"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", while in glioblastoma elevated miR-587 levels correlate with diminished tumor suppressor activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Furthermore, in epithelial ovarian cancer, overexpression of miR-587 promotes ferroptosis-related alterations that inhibit cell proliferation and migration"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", and in bladder cancer, miR-587 overexpression enhances cell proliferation and migration via targeting SLIT3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Additionally, in lung adenocarcinoma, lncRNA A2M-AS1 modulates miR-587 to influence BMP3 expression, ultimately inhibiting tumor cell growth and aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yang Zhang, G Talmon, J Wang "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2015.200"}], "href": "https://doi.org/10.1038/cddis.2015.200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26247730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26247730"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chunfeng Ren, Zhenmin Zhang, Shunhua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2019-0350"}], "href": "https://doi.org/10.1515/hsz-2019-0350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31747371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31747371"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jun Guo, Yajun Lin, Jie Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic Value of Serum MiR-587 in Patients with Metabolic Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/Clin.Lab.2019.181253"}], "href": "https://doi.org/10.7754/Clin.Lab.2019.181253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31307169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31307169"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tongtong Zhang, Hongtao Liu, Rui Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA RP11-142A22.4 promotes adipogenesis by sponging miR-587 to modulate Wnt5β expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2550-9"}], "href": "https://doi.org/10.1038/s41419-020-2550-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32561739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32561739"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Miao Chen, Duo Wang, Junjie Liu, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MicroRNA-587"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/3280530"}], "href": "https://doi.org/10.1155/2020/3280530"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32964027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32964027"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "X-J Li, L-W Chen, P Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-587 acts as an oncogene in non-small-cell lung carcinoma via reducing CYLD expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202012_24173"}], "href": "https://doi.org/10.26355/eurrev_202012_24173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33378022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33378022"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xirui Ma, Ziming Mao, Jing Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA PANTR1 Upregulates BCL2A1 Expression to Promote Tumorigenesis and Warburg Effect of Hepatocellular Carcinoma through Restraining miR-587."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/1736819"}], "href": "https://doi.org/10.1155/2021/1736819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34423048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34423048"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dong-Feng Yuan, Hao-Ran Wang, Zong-Fei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA CircZMYM4 inhibits the growth and metastasis of lung adenocarcinoma via the miR-587/ODAM pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.09.085"}], "href": "https://doi.org/10.1016/j.bbrc.2021.09.085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34634673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34634673"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kun Lin, Shang-Hang Shen, Feng Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-022-03284-z"}], "href": "https://doi.org/10.1186/s12967-022-03284-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35183197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35183197"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Li Cai, Xiaoqing Hu, Lu Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ADAMTS9-AS1 attenuates ferroptosis by Targeting microRNA-587/solute carrier family 7 member 11 axis in epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2049470"}], "href": "https://doi.org/10.1080/21655979.2022.2049470"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35311457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35311457"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xiaoyu Duan, Lingdian Wang, Zhifeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2022042376"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2022042376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36017912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36017912"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hongfei Guo, Tao Li, Chunlei Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of lncRNA A2M-AS1 inhibits cell growth and aggressiveness "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " regulating the miR-587/bone morphogenetic protein 3 axis in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Exp Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/09603271221138971"}], "href": "https://doi.org/10.1177/09603271221138971"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36461613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36461613"}]}]}]}