MIR593 Gene

HGNC Family Non-coding RNAs
Name microRNA 593
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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For example, in esophageal cancer, miR‐593* directly targets polo‐like kinase 1 (PLK1), leading to cell cycle arrest and reduced tumor formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In tongue squamous cell carcinoma, miR‐593‐5p attenuates mitochondrial fission and enhances cisplatin sensitivity by targeting the mitochondrial fission factor (MFF), a process also linked to transcriptional regulation by BRCA1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In gastric cancer and breast cancer, competing endogenous RNAs—LINC02163 and hsa_circ_0007534, respectively—sequester miR‐593 (specifically the miR‐593‐3p variant in gastric cancer) to de‐repress oncogenic targets such as FOXK1 and MUC19."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similar tumor‐suppressive attributes have been observed in non‐small cell lung cancer, where miR‐593‐5p downregulates PLK1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and in studies of colon and hepatocellular carcinoma that implicate miR‐593 in the control of malignant cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In oral squamous cell carcinoma, the lncRNA TUG1 acts as a sponge for miR‐593‐3p and thereby positively regulates MAPK signaling and epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumorigenesis, miR‐593 is also implicated in metabolic and endocrine regulation. In patients with type 2 diabetes mellitus and obesity, serum levels of miR‐593 are significantly lower, suggesting its potential utility as a non‐invasive biomarker for distinguishing these metabolic states."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In children with combined pituitary hormone deficiency, elevated circulating miR‐593—which directly targets the PROP1 gene—has been proposed as a diagnostic signature."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Moreover, in hepatocellular carcinoma cell models, miR‐593‐3p negatively regulates insulin‐induced glycolysis by targeting novel mediators such as Slc38a1 and CLIP3, thereby influencing glucose metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its oncogenic and metabolic roles, miR‐593‐5p contributes to disease processes in pulmonary and neuronal systems. Its involvement in hypoxia‐induced pulmonary hypertension points to a role in pulmonary vascular remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In the context of neurodegeneration, exposure of neuronal cells to mitochondrial toxins (MPP⁺) leads to an increase in miR‐593‐5p levels; this elevated miRNA impairs the PINK1/Parkin‐mediated mitophagy pathway by targeting the coding region of PINK1 mRNA, thereby contributing to neuronal cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tetsuo Ito, Fumiaki Sato, Takatsugu Kan, et al. 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Synonyms HSA-MIR-593, MIRN593
NCBI Gene ID 693178
API
Download Associations
Predicted Functions View MIR593's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR593's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR593's ARCHS4 Predicted Functions.

Functional Associations

MIR593 has 250 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR593 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR593 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR593 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR593 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR593 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR593 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR593 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR593 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR593 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR593 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR593 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR593 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR593 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.