{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch across multiple human diseases has revealed that miR-597, particularly the miR-597-5p isoform, plays a crucial tumor‐suppressive role. In colorectal cancer, a circular RNA (circ101555) was found to be significantly upregulated and to act as a competing endogenous RNA that sponges miR-597-5p, leading to the derepression of its oncogenic targets CDK6 and RPA3, thereby promoting tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer, miR-597 is markedly downregulated, and its enforced expression reduces cellular proliferation, migration, and invasion through the direct targeting of FOSL2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in cutaneous squamous cell carcinoma, increased levels of circRNA_001937 contribute to oncogenesis by sponging miR-597-3p and indirectly augmenting FOSL2 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic cancer, the downregulation of miR-597-5p is associated with enhanced tumor cell viability, migration, and invasion. Restoration of miR-597-5p impairs these malignant properties by targeting the oncogene ELK1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In non-small cell lung cancer, emerging evidence reinforces the concept of miR-597 functioning as a tumor suppressor"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in nasopharyngeal carcinoma, changes in microRNA expression patterns, including that of miR-597, are linked to tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Hepatocellular carcinoma (HCC) studies further elucidate the tumor-inhibitory effects of miR-597, with one study showing that miR-597-5p attenuates cell proliferation and invasion via direct downregulation of TEAD1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and another highlighting that lncRNA GSTM3TV2 exerts oncogenic functions by binding to miR-597 and thereby stabilizing FOSL2 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer, miR-597-5p is implicated in non-neoplastic diseases. In acute kidney injury induced by vancomycin, proximal tubular MBD2 promotes autophagy and apoptosis by activating miR-597-5p through promoter demethylation, which in turn suppresses S1PR1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, in the context of myelodysplastic syndrome—especially with trisomy 8—miR-597-5p has been reported to induce cell death across various cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhenlong Chen, Rui Ren, Daiwei Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_101555 functions as a competing endogenous RNA of miR-597-5p to promote colorectal cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-019-0857-8"}], "href": "https://doi.org/10.1038/s41388-019-0857-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31300733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31300733"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jiangtu He, Jieying Mai, Yan Li, et al. 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