MIR603 Gene

HGNC Family Non-coding RNAs
Name microRNA 603
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‑603 exhibits diverse, context‐dependent functions across multiple human diseases. In gliomas, miR‑603 is overexpressed and acts in an oncogenic manner by promoting cell proliferation, cell cycle progression, and neurosphere formation via repression of negative regulators of the Wnt/β‑catenin pathway (e.g. WIF1 and CTNNBIP1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer, a single nucleotide polymorphism in the miR‑603 precursor (rs11014002) is associated with a decreased risk, suggesting a protective role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In osteosarcoma, miR‑603 is significantly upregulated and enhances tumor growth by translationally repressing the tumor suppressor BRCC2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while in ovarian cancer, lower levels of miR‑603 in patient tissues correlate with malignancy, and restoration of miR‑603 inhibits the Warburg effect and subsequent proliferation, migration, and invasion through direct targeting of hexokinase‑2 (HK2)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in tumor biology, miR‑603 has implications in neurological disorders and hematologic malignancies. In Alzheimer’s disease, enhanced biogenesis of miR‑603—promoted by a protective rs11014002 SNP—leads to downregulation of LRPAP1 and consequent increased expression of LRP1, a critical mediator of Aβ clearance, as well as modulation of neuronal apoptosis via E2F1 suppression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Preliminary investigations in cutaneous melanoma point to an important regulatory function of miR‑603, although the underlying mechanisms remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, in acute promyelocytic leukemia, relapsed patients exhibit markedly lower miR‑603 levels; experimental overexpression of miR‑603 in NB4 leukemia cells directly targets tropomyosin‑related kinase B (TrkB), promoting differentiation and reducing apoptosis, thereby highlighting the miR‑603/TrkB axis as a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mian Guo, Xiaoming Zhang, Guangzhi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-603 promotes glioma cell growth via Wnt/β-catenin pathway by inhibiting WIF1 and CTNNBIP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.02.003"}], "href": "https://doi.org/10.1016/j.canlet.2015.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25681036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25681036"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "M Hashemi, S Sanaei, M A Mashhadi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association study of hsa-mir-603 rs11014002 polymorphism and risk of breast cancer in a sample of Iranian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26718432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26718432"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chengbin Ma, Chuan Zhan, Hongmou Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-603 functions as an oncogene by suppressing BRCC2 protein translation in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.4718"}], "href": "https://doi.org/10.3892/or.2016.4718"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27035098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27035098"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiaojiao Lu, Lijie Wang, Wei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2018.10.014"}], "href": "https://doi.org/10.1016/j.abb.2018.10.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30365936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30365936"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chi Zhang, Jie Lu, Bing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.100887"}], "href": "https://doi.org/10.18632/aging.100887"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26856603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26856603"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xianghua Dong, Ying Wang, Yan Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-603 Promotes Progression of Cutaneous Melanoma by Regulating TBX5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/1888501"}], "href": "https://doi.org/10.1155/2021/1888501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35003317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35003317"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Huibo Li, Jinxiao Hou, Yueyue Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hematol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00277-023-05441-w"}], "href": "https://doi.org/10.1007/s00277-023-05441-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37726492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37726492"}]}]}]}
Synonyms HSA-MIR-603, MIRN603
NCBI Gene ID 693188
API
Download Associations
Predicted Functions View MIR603's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR603's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR603's ARCHS4 Predicted Functions.

Functional Associations

MIR603 has 221 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR603 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR603 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR603 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR603 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR603 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR603 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR603 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR603 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR603 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR603 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR603 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR603 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR603 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR603 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.